2-Chloro-4-(trifluoromethyl)pyridine
2-Chloro-4-(trifluoromethyl)pyridine
CAS: 81565-18-6
Molecular Formula: C6H3ClF3N
2-Chloro-4-(trifluoromethyl)pyridine - Names and Identifiers
| Name | 2-Chloro-4-(trifluoromethyl)pyridine |
| Synonyms | oro-4-(trifL 2-Chloro-4-(trifluor 2-Chloro-4-(trifluoromethyl)pyridine 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE Pyridine,2-chloro-4-(trifluoromethyl)- ethyl [2-(trifluoromethyl)phenyl]acetate 2-Chloro-alpha,alpha,alpha-trifluoro-4-picoline |
| CAS | 81565-18-6 |
| EINECS | 617-242-3 |
| InChI | InChI=1/C11H11F3O2/c1-2-16-10(15)7-8-5-3-4-6-9(8)11(12,13)14/h3-6H,2,7H2,1H3 |
2-Chloro-4-(trifluoromethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C6H3ClF3N |
| Molar Mass | 181.54 |
| Density | 1.411g/mLat 25°C(lit.) |
| Melting Point | -19°C |
| Boling Point | 146-147°C(lit.) |
| Flash Point | 127°F |
| Solubility | Chloroform, Methanol (Sparingly) |
| Vapor Presure | 0.0688mmHg at 25°C |
| Appearance | Oil |
| Color | Colourless |
| BRN | 4246276 |
| pKa | -1.34±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.4490(lit.) |
| Physical and Chemical Properties | Melting Point -19°C boiling point 146-147°C(lit.) density 1.411g/mL at 25°C(lit.) refractive index n20/D 1.4490(lit.) flash point 127 °F BRN 4246276 |
2-Chloro-4-(trifluoromethyl)pyridine - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | III |
2-Chloro-4-(trifluoromethyl)pyridine - Introduction
2-Chloro-4-(trifluoromethyl)pyridine is an organic compound with the formula C6H3ClF3N. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Chloro-4-(trifluoromethyl)pyridine is a colorless liquid.
-Melting point:-3 ℃
-Boiling point: 98 ℃
-Density: 1.50g/cm³
-Solubility: It is insoluble in water, but can be dissolved in organic solvents.
Use:
- 2-Chloro-4-(trifluoromethyl)pyridine can be used as an important intermediate in organic synthesis. It is widely used in the fields of drugs, dyes and pesticides.
-It can also be used to prepare other organic compounds, such as heterocyclic compounds and crown ether derivatives.
Preparation Method:
2-Chloro-4-(trifluoromethyl)pyridine can be prepared by reacting 2-chloro-4-nitropyridine with trifluoromethyl fluoroformate under basic conditions. The reaction process is usually carried out at low temperature.
Safety Information:
- 2-Chloro-4-(trifluoromethyl)pyridine is an organic compound with certain toxicity and irritation. Use should follow appropriate laboratory procedures and take necessary safety measures, such as wearing protective glasses, gloves and laboratory coats.
-Avoid contact with skin, eyes and respiratory tract. If exposed to this substance, immediately flush the affected area with plenty of flowing water and seek medical help.
-Store in a closed container, away from fire and oxidizing agents.
Nature:
-Appearance: 2-Chloro-4-(trifluoromethyl)pyridine is a colorless liquid.
-Melting point:-3 ℃
-Boiling point: 98 ℃
-Density: 1.50g/cm³
-Solubility: It is insoluble in water, but can be dissolved in organic solvents.
Use:
- 2-Chloro-4-(trifluoromethyl)pyridine can be used as an important intermediate in organic synthesis. It is widely used in the fields of drugs, dyes and pesticides.
-It can also be used to prepare other organic compounds, such as heterocyclic compounds and crown ether derivatives.
Preparation Method:
2-Chloro-4-(trifluoromethyl)pyridine can be prepared by reacting 2-chloro-4-nitropyridine with trifluoromethyl fluoroformate under basic conditions. The reaction process is usually carried out at low temperature.
Safety Information:
- 2-Chloro-4-(trifluoromethyl)pyridine is an organic compound with certain toxicity and irritation. Use should follow appropriate laboratory procedures and take necessary safety measures, such as wearing protective glasses, gloves and laboratory coats.
-Avoid contact with skin, eyes and respiratory tract. If exposed to this substance, immediately flush the affected area with plenty of flowing water and seek medical help.
-Store in a closed container, away from fire and oxidizing agents.
Last Update：2024-04-09 15:18:00
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