2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, monosodium salt, (R-(R*,S*-(Z)))-

Name	Cilastatin sodium
Synonyms	MK 791 l642957 MK 0791 L 642957 Primaxin Cilastatine UNII-5428WXZ74M Cilastatin sodium Cilastatin natrium monosodiumsalt,(r-(r,s(z)))-)carbonyl)amino) 2-heptenoicacid,7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl Sodium 7-(2-amino-2-carboxy-ethyl)sulfanyl-2-(2,2-dimethylcyclopropyl)carbonylamino-hept-2-enoate Sodium (Z)-7-(((R)-2-amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoate Sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate sodium (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoate sodium (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoate Sodium hydrogen (R-(R,S-(Z)))-7-((2-amino-2-carboxylatoethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)hept-2-enoate sodium hydrogen [R-[R,S-(Z)]]-7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, monosodium salt, (R-(R,S-(Z)))-
CAS	81129-83-1
EINECS	279-694-4
InChI	InChI=1/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1

Molecular Formula	C16H25N2O5S.Na
Molar Mass	380.44
Melting Point	>160°C (dec.)
Boling Point	655.5°C at 760 mmHg
Flash Point	87℃
Solubility	Very soluble in water and in methanol, slightly soluble in anhydrous ethanol, very slightly soluble in dimethyl sulfoxide, practically insoluble in acetone and in methylene chloride.
Vapor Presure	7.13E-19mmHg at 25°C
Appearance	neat
Color	White
pKa	pKa1 2.0; pKa2 4.4; pKa3 9.2(at 25℃)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Physical and Chemical Properties	White crystalline powder.
In vivo study	In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice from S. aureus , E. coli , and P. aeruginosa infection.

RTECS

MJ9650200

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2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, monosodium salt, (R-(R,S-(Z)))-