2-METHYOXY-4-METHYL-6-HYDROXY PYRIMIDINE

2-METHYOXY-4-METHYL-6-HYDROXY PYRIMIDINE - Names and Identifiers

Name	2-methoxy-4-methyl-6-hydroxypyrimidine
Synonyms	2-methoxy-6-methylpyrimidin-4-ol 2-Methoxy-6-Methyl-5H-pyriMidin-4-one 2-methoxy-6-methylpyrimidin-4(1H)-one 2-Methoxy-6-methyl-4(3H)-pyrimidinone 2-METHOXY-6-METHYL-4(1H)-PYRIMIDINONE 4-Hydroxy-2-methoxy-6-methylpyrimidine 2-methoxy-4-methyl-6-hydroxypyrimidine 2-METHYOXY-4-METHYL-6-HYDROXY PYRIMIDINE 4(1H)-Pyrimidinone, 2-methoxy-6-methyl- (9CI) 2-Methoxy-6-Methyl-1,4-dihydropyriMidin-4-one
CAS	55996-28-6
InChI	InChI=1/C6H8N2O2/c1-4-3-5(9)8-6(7-4)10-2/h3H,1-2H3,(H,7,8,9)

2-METHYOXY-4-METHYL-6-HYDROXY PYRIMIDINE - Physico-chemical Properties

Molecular Formula	C6H8N2O2
Molar Mass	140.14
Density	1.25±0.1 g/cm3(Predicted)
Melting Point	207-209℃
Boling Point	203.0±23.0 °C(Predicted)
Flash Point	76.563°C
Vapor Presure	0.284mmHg at 25°C
pKa	8.67±0.50(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.55

2-METHYOXY-4-METHYL-6-HYDROXY PYRIMIDINE - Reference Information

Use

2-methoxy-4-methyl-6-hydroxypyrimidine, it is an intermediate of the organic phosphorus insecticide pyrimidine oxygen phosphorus.

production method

the production method is to obtain methylpyridinol by cyclization of O-methylisourea salt with ethyl acetoacetate. Put 200L water and 370kg isourea salt in 1500L reactor, stir and cool to 0~5 ℃, slowly add 390kg lye (30%), keep the temperature not more than 15 ℃, then 300kg of ethyl acetoacetate was added dropwise, and the reaction was maintained at 15 ℃ for 16h after the addition. 30% hydrochloric acid neutralization solution was added dropwise to make pH = 6, about 100kg hydrochloric acid was needed, and the mixture was stirred for 2H and filtered, the filter cake was washed with a small amount of water, I .e., the intermediate methyl pyridinol. Methyl pyridinol is a crystalline solid. Solubility in organic solvents: Chloroform ≥ 3.46g/100g, ethyl acetate 0.713g/100g, dichloromethane 0.681g/100g, cyclohexane 0.522g/100g, dichloroethane 0.280g/100g, butyl acetate 0.184g/0.140g, benzene 0.091g/0.066g, chlorobenzene g/g, toluene g/100g. The solubility in water is 1g/100g of water.

Last Update：2024-04-09 18:58:34