2-Methylcitric acid trisodium
Trisodium (2RS,3RS)-2-methylcitrate
CAS: 117041-96-0
Molecular Formula: C7H7O7*3Na
2-Methylcitric acid trisodium - Names and Identifiers
2-Methylcitric acid trisodium - Physico-chemical Properties
| Molecular Formula | C7H7O7*3Na |
| Molar Mass | 230.15 |
| In vitro study | 2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM. 2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca 2+ -loaded mitochondria supported by different substrates. 2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria. |
2-Methylcitric acid trisodium - Risk and Safety
| WGK Germany | 3 |
2-Methylcitric acid trisodium - References
| biological activity | 2-Methylcitric acid trisodium is an endogenous metabolite of the 2-Methylcitric acid cycle. 2-methylcellulose acid trisodium accumulates in methylmalonic acidemia and malonic acidemia and can serve as a metabolic marker. 2-methylcellulose acid trisodium has a significant inhibitory effect on ADP stimulation and uncoupled respiration in glutamate-supported mitochondria. |
Last Update：2024-04-09 20:45:29
