Name | Sodium L-ascorbyl-2-phosphate |
Synonyms | SAP Sodium L-ascorbyl-2- L-Ascorbic-2-Phosphate Sodium Ascorbyl Phosphate Vitamin C sodium phosphate Sodium L-ascorbyl-2-phosphate L-Ascorbic acid-2-phosphate sodium 2-PHOSPHO-L-ASCORBIC ACID TRISODIUM 2-Phospho-L-ascorbic acid trisodium salt L-Ascorbic acid 2-phosphate trisodium salt 2-(Dihydrogen phosphate)-L-ascorbic acid sodium salt L-Ascorbic acid 2-phosphate trisodium salt, Sodium L-ascorbyl-2-phosphate SodiuM (R)-5-((S)-1,2-dihydroxyethyl)-4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl phosphate |
CAS | 66170-10-3 |
EINECS | 1308068-626-2 |
InChI | InChI=1/C6H8O6.3Na.H3O4P/c7-1-2(8)5-3(9)4(10)6(11)12-5;;;;1-5(2,3)4/h2,5,7-10H,1H2;;;;(H3,1,2,3,4)/q;3*+1;/p-3/t2-,5+;;;;/m0..../s1 |
InChIKey | YRWWOAFMPXPHEJ-OFBPEYICSA-K |
Molecular Formula | C6H10NaO9P |
Molar Mass | 280.1 |
Density | 1.94[at 20℃] |
Melting Point | 260 °C |
Water Solubility | 789g/L at 20℃ |
Solubility | Acidic DMSO (Slightly), Water (Slightly) |
Appearance | Solid |
Color | White to Off-White |
PH | 9.0-9.5 (25℃, 30g/L in H2O) |
Storage Condition | Inert atmosphere,Room Temperature |
Sensitive | Easily absorbing moisture |
In vitro study | 2-Phospho-L-ascorbic acid (Asc 2-P) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. 2-Phospho-L-ascorbic acid is a stable derivative of L-ascorbic acid (AA) and possesses similar biological properties as AA. AA and Asc-2P regulate a number of biological processes. When 2-Phospho-L-ascorbic acid is added together with DHT, DHT-induced DKK-1 mRNA expression in DPCs is significantly attenuated. It is also found that DKK-1 promoter activity is increased by DHT treatmen. When 2-Phospho-L-ascorbic acid is added together with DHT, DHT-induced activation of luciferase activity is significantly repressed. |
WGK Germany | 3 |
Reference Show more | 1. Qu, Fei, et al. "Fluorescent Detection of 2, 4-Dichlorophenoxyacetic Acid in Food Samples Based on Covalent Organic Frameworks and MnO 2 Nanosheets." Food Analytical Methods 13.10 (2020): 1842-1851.https://doi.org/10.1007/s12161-020-01807-2 2. [IF=7.46] Shi Gang Liu et al."A ratiometric fluorescent strategy for alkaline phosphatase activity assay based on g-C3N4/CoOOH nanohybrid via target-triggered competitive redox reaction."Sensor Actuat B-Chem. 2019 Mar;283:515 3. [IF=6.558] Yu-Ting Gong et al."Switched photoelectrochemistry of carbon dots for split-type immunoassay."Anal Chim Acta. 2018 Jul;1014:19 4. [IF=6.331] Shi Gang Liu et al."A fluorescence and colorimetric dual-mode assay of alkaline phosphatase activity via destroying oxidase-like CoOOH nanoflakes."J Mater Chem B. 2018 May;6(18):2843-2850 5. [IF=6.558] Tianran Lin et al."Multicolor and photothermal dual-mode assay of alkaline phosphatase based on the UV light-assisted etching of gold nanorods."Anal Chim Acta. 2021 Oct;1181:338926 6. [IF=4.749] Jing Wang et al."Label-Free Colorimetric Detection of Acid Phosphatase and Screening of Its Inhibitors Based on Biomimetic Oxidase Activity of MnO2 Nanosheets."Acs Biomater Sci Eng. 2020;6(5):3132–3138 7. [IF=4.142] Qu Fei et al."Ratiometric detection of alkaline phosphatase based on aggregation-induced emission enhancement."Anal Bioanal Chem. 2019 Nov;411(28):7431-7440 8. [IF=3.935] Li Hou et al."A ratiometric electrochemical biosensor via alkaline phosphatase mediated dissolution of nano-MnO2 and Ru(III) redox recycling for the determination of dimethoate."J Pharmaceut Biomed. 2022 Jan;207:114400 9. [IF=3.594] Hongwei He et al."Highly sensitive detection of salbutamol by ALP-mediated plasmonic ELISA based on controlled growth of AgNPs."Microchem J. 2020 Jul;156:104804 |
Introduction | L-ascorbic acid -2-phosphate trisodium salt Chinese alias vitamin C phosphate sodium, SAP, L-ascorbic acid -2-phosphate sodium salt. L-ascorbic acid -2-phosphate trisodium salt can be used as pharmaceutical chemical synthesis intermediates. |
Use | This product is used in scientific research reagents, widely used in molecular biology, pharmacology and other scientific research, and is strictly prohibited for human body. L-ascorbic acid -2-phosphate (AA2P) is used for biocatalytic dephosphorylation, for power generation and electrochemical detection assays. L-ascorbic acid 2-phosphate is useful for cell differentiation and tissue engineering applications. Asc-2P for gene suppression studies such as inhibition of dihydrotestosterone induced expression by dickkopf-1. L-ascorbic acid -2-phosphate trisodium salt can also be used as alkaline phosphatase catalytic substrate. Alkaline phosphatase (ALP) is an important biomarker, and its abnormal expression is associated with breast cancer, prostate cancer, bone disease, diabetes and liver dysfunction. It can also be used in the preparation of a photoelectric chemical parathion sensor. |
biological activity | 2-phosphate-L-ascorbic acid trisodium salt acts as antioxidant and hepatocyte growth factor (HGF) the stimulus produced. in vitro study of 2-phosphate-L-ascorbic acid (Asc 2-P) acting as an antioxidant and stimulator of hepatocyte growth factor (HGF) production. 2-phosphate-L-ascorbic acid is a stable derivative of L-ascorbic acid (AA) with biological properties similar to AA. AA and Asc-2P regulate many biological processes. When 2-phosphate-L-ascorbic acid was added together with DHT, DHT-induced DKK-1 mRNA expression in DPC was significantly attenuated. DHT treatment was also found to increase promoter activity by DKK-1. When 2-phosphate-L-ascorbic acid was added together with DHT, DHT-induced activation of luciferase activity was significantly inhibited. |
precautions | if L-ascorbic acid -2-phosphate trisodium salt is inhaled, move the patient to fresh air; if the skin is in contact, take off the contaminated clothing and rinse the skin thoroughly with soap and water. If you feel uncomfortable, seek medical advice, and immediately see a doctor; If you eat, immediately gargle, prohibit emetic, should immediately see a doctor. |
Target | Value |