2-Picoline-5-boronic acid
6-Methylpyridine-3-boronic acid
CAS: 659742-21-9
Molecular Formula: C6H8BNO2
2-Picoline-5-boronic acid - Names and Identifiers
2-Picoline-5-boronic acid - Physico-chemical Properties
| Molecular Formula | C6H8BNO2 |
| Molar Mass | 136.94 |
| Density | 1.18±0.1 g/cm3(Predicted) |
| Melting Point | 128-130°C |
| Boling Point | 294.7±42.0 °C(Predicted) |
| Flash Point | 132.002°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.001mmHg at 25°C |
| Appearance | Powder |
| Color | White to pale brown |
| pKa | 4.27±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.528 |
2-Picoline-5-boronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
2-Picoline-5-boronic acid - Introduction
6-Methylpyridine-3-boronic acid is an organic boron compound with the chemical formula C6H8BNO2. Its nature is as follows:
1. Appearance: Colorless crystalline solid.
2. solubility: can be dissolved in water, alcohol and organic solvents.
3. Melting point: about 169-172°C.
The main uses of 6-Methylpyridine-3-boronic acid are as follows:
1. Organic synthesis reaction: As one of the important derivatives of organometallic reagents, it can be used to participate in organic synthesis reactions such as Suzuki reaction and C- H bond activation.
2. Drug synthesis: It can be used as an intermediate in drug development and participate in drug synthesis and improvement.
3. material synthesis: can be used as a fluorescent probe, polymerization catalyst materials such as synthetic raw materials.
The methods for preparing 6-Methylpyridine-3-boronic acid are generally as follows:
1. Suzuki reaction: It is synthesized by the reaction of 2-methyl-5-bromopyridine and phenylboronic acid under alkali catalysis.
2. Boronic Ester method: it is obtained by etherifying 2-methyl -5-bromopyridine with tert-butyl alcohol and then borating.
The security information for 6-Methylpyridine-3-boronic acid is as follows:
1. ignition point: the ignition point of this compound is 210 c, which can be ignited.
2. Stability: Stable at room temperature, but may decompose when heated and release harmful gases.
3. safe operation: use should wear appropriate protective equipment, avoid contact with skin and eyes. Avoid inhalation and ingestion.
1. Appearance: Colorless crystalline solid.
2. solubility: can be dissolved in water, alcohol and organic solvents.
3. Melting point: about 169-172°C.
The main uses of 6-Methylpyridine-3-boronic acid are as follows:
1. Organic synthesis reaction: As one of the important derivatives of organometallic reagents, it can be used to participate in organic synthesis reactions such as Suzuki reaction and C- H bond activation.
2. Drug synthesis: It can be used as an intermediate in drug development and participate in drug synthesis and improvement.
3. material synthesis: can be used as a fluorescent probe, polymerization catalyst materials such as synthetic raw materials.
The methods for preparing 6-Methylpyridine-3-boronic acid are generally as follows:
1. Suzuki reaction: It is synthesized by the reaction of 2-methyl-5-bromopyridine and phenylboronic acid under alkali catalysis.
2. Boronic Ester method: it is obtained by etherifying 2-methyl -5-bromopyridine with tert-butyl alcohol and then borating.
The security information for 6-Methylpyridine-3-boronic acid is as follows:
1. ignition point: the ignition point of this compound is 210 c, which can be ignited.
2. Stability: Stable at room temperature, but may decompose when heated and release harmful gases.
3. safe operation: use should wear appropriate protective equipment, avoid contact with skin and eyes. Avoid inhalation and ingestion.
Last Update：2024-04-09 02:00:47
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