2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)-
DMU2105
CAS: 1031063-36-1
Molecular Formula: C18H13NO
2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)- - Names and Identifiers
| Name | DMU2105 |
| Synonyms | DMU2105 CS-2868 DMU 2105 DMU-2105 DMU-2105(CYP1B1 inhibitor 7k) 2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)- |
| CAS | 1031063-36-1 |
2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)- - Physico-chemical Properties
| Molecular Formula | C18H13NO |
| Molar Mass | 259.3 |
| Density | 1.194±0.06 g/cm3(Predicted) |
| Boling Point | 463.7±37.0 °C(Predicted) |
| pKa | 2.98±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | DMU-2105 is a potent and selective CYP1B1 inhibitor with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. DMU-2105 showed a very high level of selectivity towards CYP1B1 with respect to the IC50 values obtained with CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2C9 and CYP2C19 Sacchrosomes™. |
2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)- - Reference
| Reference Show more | Horley NJ, Beresford KJ, Chawla T, McCann GJ, Ruparelia KC, Gatchie L, Sonawane VR, Williams IS, Tan HL, Joshi P, Bharate SS, Kumar V, Bharate SB, Chaudhuri B. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. doi: 10.1016/j.ejmech.2017.02.016. Epub 2017 Feb 9. PMID: 28222316. |
2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)- - Reference Information
| biological activity | DMU2105 is an effective and specific CYP1B1 inhibitor with an IC50 value of 10 nM. |
| target | TargetValue CYP1B1 (Cell-free say) 10 nM |
| Target | Value |
| CYP1B1 (Cell-free assay) | 10 nM |
Last Update：2024-04-09 02:00:00
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Product Name: DMU2105 Visit Supplier Webpage Request for quotationCAS: 1031063-36-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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