2-bromo-1-(1,3-thiazol-2-yl)-1-ethanone
2-(Bromoacetyl)-1,3-thiazole
CAS: 3292-77-1
Molecular Formula: C5H4BrNOS
2-bromo-1-(1,3-thiazol-2-yl)-1-ethanone - Names and Identifiers
2-bromo-1-(1,3-thiazol-2-yl)-1-ethanone - Physico-chemical Properties
| Molecular Formula | C5H4BrNOS |
| Molar Mass | 206.06 |
| Density | 1.763±0.06 g/cm3(Predicted) |
| Melting Point | 54-55 |
| Boling Point | 266.7±42.0 °C(Predicted) |
| Flash Point | 115.091°C |
| Solubility | Acetonitrile (Slightly), Chloroform (Sparingly) |
| Vapor Presure | 0.009mmHg at 25°C |
| Appearance | Solid |
| Color | Orange to Dark Orange |
| pKa | -0.40±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Light Sensitive, Moisture Sensitive |
| Refractive Index | 1.61 |
2-bromo-1-(1,3-thiazol-2-yl)-1-ethanone - Risk and Safety
| Risk Codes | R34 - Causes burns R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| Hazard Note | Corrosive |
| Hazard Class | IRRITANT |
2-bromo-1-(1,3-thiazol-2-yl)-1-ethanone - Introduction
2-(Bromoacetyl)-1,3-thiazole is an organic compound with the chemical formula C5H4BrNOS. The following is a description of the properties, uses, preparation and safety information of the compound:
Properties: 2-(Bromoacetyl)-1,3-thiazole is a yellow to orange solid. It has a melting point of about 40-42 degrees Celsius and a density of about 1.728g/cm³. The compound is stable at room temperature and slightly unstable under light. It can be dissolved in some organic solvents, such as chloroform, ether and dimethyl sulfoxide.
Uses: 2-(Bromoacetyl)-1,3-thiazole is widely used as a functionalization reagent and intermediate in organic synthesis. It can be used to synthesize compounds with pharmacological activity, including antitumor agents and antibacterial agents, etc. In addition, it is also used in the manufacturing process of pesticides and dyes.
Preparation method: A common synthesis method is to react 1,3-thiazole with Bromoacetyl chloride to generate the target product 2-(Bromoacetyl)-1,3-thiazole. This reaction can be carried out at room temperature and usually requires the presence of a drying agent.
Safety Information: 2-(Bromoacetyl)-1,3-thiazole is a highly irritating substance that may cause inflammation and irritation in contact with the skin and eyes. Wear appropriate protective equipment such as safety glasses and gloves when handling. In addition, it may cause harm to aquatic life and the environment, so appropriate environmental protection measures should be taken during use, handling and disposal. During storage, it should be stored in a dry, ventilated and away from fire.
Properties: 2-(Bromoacetyl)-1,3-thiazole is a yellow to orange solid. It has a melting point of about 40-42 degrees Celsius and a density of about 1.728g/cm³. The compound is stable at room temperature and slightly unstable under light. It can be dissolved in some organic solvents, such as chloroform, ether and dimethyl sulfoxide.
Uses: 2-(Bromoacetyl)-1,3-thiazole is widely used as a functionalization reagent and intermediate in organic synthesis. It can be used to synthesize compounds with pharmacological activity, including antitumor agents and antibacterial agents, etc. In addition, it is also used in the manufacturing process of pesticides and dyes.
Preparation method: A common synthesis method is to react 1,3-thiazole with Bromoacetyl chloride to generate the target product 2-(Bromoacetyl)-1,3-thiazole. This reaction can be carried out at room temperature and usually requires the presence of a drying agent.
Safety Information: 2-(Bromoacetyl)-1,3-thiazole is a highly irritating substance that may cause inflammation and irritation in contact with the skin and eyes. Wear appropriate protective equipment such as safety glasses and gloves when handling. In addition, it may cause harm to aquatic life and the environment, so appropriate environmental protection measures should be taken during use, handling and disposal. During storage, it should be stored in a dry, ventilated and away from fire.
Last Update：2024-04-10 22:29:15
