Molecular Formula | C11H13NO3S |
Molar Mass | 239.29 |
Density | 1.305±0.06 g/cm3(Predicted) |
Melting Point | 39.5-40.2 °C |
Boling Point | 121-128 °C(Press: 0.06 Torr) |
pKa | -12.87±0.20(Predicted) |
osmotic effect of thiazone | according to the regulations of the Ministry of health, a new type of osmotic agent must pass the drug test and osmotic effect test stipulated by the Ministry of health to declare its drug number. Howl ketone showed high osmotic effect and satisfactory drug test results in the test. |
osmotic mechanism of thiazone | osmotic mechanism test of thiazone shows that when thiazone interacts with erythrocyte membrane, the function of membrane binding water decreases, thus significantly reducing the effect between hydrocarbon chains, thus reducing the rigidity of lipid molecules, increasing the fluidity of the membrane, making the membrane easily damaged and enhancing the permeability. Because the bilayer in the intercellular space of the skin lipid layer is similar to the lipid bilayer of the erythrocyte membrane, thiazone appeared in the experiment to damage the erythrocyte membrane and hemolysis. The experiment shows that the mechanism of thalidone and azone is similar, and the drug realizes the process of transdermal absorption under the action of penetration enhancer. The drug first penetrates into the cuticle, then enters the dermis, and further reaches the capillaries of subcutaneous fat, which are absorbed by the capillaries into the blood circulation. If the external medicine is not added with penetration enhancers, it is difficult to overcome the barrier function of the skin and realize the therapeutic effect. Now with penetration enhancers, about 2/3 of the drugs can be delivered transdermal absorption. |
application of thalidone in medicine | after satisfactory results were obtained in various tests, preliminary clinical trials were carried out. Seven diseases (dermatitis, tinea pedis, tinea cruris, eczema, acne, multiple trichoderitis) with no penetration enhancer were selected, and 1% thiazone was added instead. There are 5 dosage forms (ointment, cream, emulsion, aqueous solution and plaster). The test results show that 75 cases have improved the curative effect to varying degrees. Among them, the effect of acetic acid deyansong ointment on eczema is the most obvious, and the effect is obvious the next day after medication, and the cured skin is the same as normal skin. However, it should be noted that petroleum products such as vaseline cannot be mixed into the preparation, otherwise the penetration promoting effect of the penetration enhancer will be reduced or even completely lost |