2-tert-Butoxycarbonylamino-5-hydroxybenzoic acid

2-tert-Butoxycarbonylamino-5-hydroxybenzoic acid - Names and Identifiers

Name	2-[(tert-butoxycarbonyl)amino]-5-hydroxybenzoic acid
Synonyms	N-BOC-5-HYDROXYANTHRANILIC ACID 2-tert-Butoxycarbonylamino-5-hydroxybenzoic acid 2-[N-(tert-butoxy)forMaMido]-5-hydroxybenzoic acid 2-[(tert-butoxycarbonyl)amino]-5-hydroxybenzoic acid 2-[(tert-Butoxycarbonyl)amino]-5-hydroxybenzoic acid Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-hydroxy-
CAS	244765-00-2
InChI	InChI=1/C12H15NO5/c1-12(2,3)18-11(17)13-9-5-4-7(14)6-8(9)10(15)16/h4-6,14H,1-3H3,(H,13,17)(H,15,16)

2-tert-Butoxycarbonylamino-5-hydroxybenzoic acid - Physico-chemical Properties

Molecular Formula	C12H15NO5
Molar Mass	253.25
Density	1.337±0.06 g/cm3(Predicted)
Boling Point	385.6±37.0 °C(Predicted)
Flash Point	187°C
Vapor Presure	1.23E-06mmHg at 25°C
pKa	3.58±0.36(Predicted)
Storage Condition	2-8℃
Refractive Index	1.601

2-tert-Butoxycarbonylamino-5-hydroxybenzoic acid - Introduction

2-[(tert-butoxycarbonyl)amino]-5-hydroxybenzoic acid is an organic compound, also known as Boc-amino acid. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White solid
-Molecular formula: C13H17NO4
-Molecular weight: 247.28g/mol
-Melting Point: about 125 ° C
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dimethylformamide, insoluble in water.
-Chemical properties: The compound has the structural characteristics of amide and hydroxy acid, which can be converted into 2-amino-5-hydroxybenzoic acid through hydrolysis reaction.

Use:
-Commonly used in the field of organic synthesis as a precursor compound of a protecting group (Boc protecting group). The protecting group can be removed by chemical reaction to give the desired functional group.
-Widely used in peptide and protein synthesis to protect the α-amino group of amino acids to prevent accidental substitution or reaction during the reaction.
-In drug development, it can be used to synthesize new drug molecules.

Method:
-2-[(tert-butoxycarbonyl)amino]-5-hydroxybenzoic acid can be produced by reacting 2-amino-5-hydroxybenzoic acid with tert-butyl isocyanate.

Safety Information:
-The compound may be irritating to the skin and eyes, please pay attention to safe operation.
-Wear appropriate protective equipment such as lab gloves and goggles to avoid contact and inhalation during use.
-Follow proper operating procedures and proper laboratory safety measures, such as operating in a well-ventilated environment.

Last Update：2024-04-09 15:17:56