20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine
:O-(2-AMinoethyl)-O'-(2-azidoethyl)pentaethylene Glycol
CAS: 957486-82-7
Molecular Formula: C22H46N4O10
20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine - Names and Identifiers
| Name | :O-(2-AMinoethyl)-O'-(2-azidoethyl)pentaethylene Glycol |
| Synonyms | AZIDO-PEG-AMINE Azido-PEG6-amine AZIDO-PEG6-AMINE,N3-PEG6-NH2 20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine O-(2-AMINOETHYL)-O'-(2-AZIDOETHYL)NONAETHYLENE GLYCOL O-(2-AMINOETHYL)-O'-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL O-(2-AMINOETHYL)-O'-(2-AZIDOETHYL)PENTAETHYLENE GLYCOL 2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| CAS | 957486-82-7 |
| InChIKey | RMNAJNJBCBFOKX-UHFFFAOYSA-N |
20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine - Physico-chemical Properties
| Molecular Formula | C22H46N4O10 |
| Molar Mass | 526.62 |
| Storage Condition | 2-8°C |
| MDL | MFCD03453240 |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine - Reference Information
| biological activity | Azido-PEG6-amine is a PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. Azido-PEG6-amine is also a non-cleavable ADC linker containing 6-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). |
| target | PEGs Non-cleavable |
| in vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
Last Update：2024-04-09 21:04:16
