203923-89-1

Name	Karenitecin
Synonyms	DB 172 BNP 1350 MCC 12824 Cositecan Karenitecin
CAS	203923-89-1

Molecular Formula	C25H28N2O4Si
Molar Mass	448.59
Density	1.29±0.1 g/cm3(Predicted)
Boling Point	727.2±60.0 °C(Predicted)
Solubility	Soluble in DMSO, insoluble in water
pKa	11.27±0.20(Predicted)
Storage Condition	2-8℃
MDL	MFCD09833216
In vitro study	Karenitecin is a topoisomerase I inhibitor, with potent anti-cancer activity. Karenitecin inhibits cell growth of A253 cells with IC 10 , IC 50 , and IC 90 values of 0.01, 0.07, and 0.7 μM after 2 h treatment. Karenitecin induces DNA damage (0.01, 0.07, and 0.7 μM), and increases cyclin E and cdk2 protein expression in A253 cells (0.07, and 0.7 μM). Karenitecin markedly enhances the cyclin B/cdc2-associated kinase activity at low concentration, but slightly suppresses this kinase activity at higher concentration. Karenitecin inhibits several human colon cancer cell lines such as COLO205, COLO320, LS174T, SW1398 and WiDr cells, with IC 50 s of 2.4 nM, 1.5 nM, 1.6 nM, 2.9 nM, and 3.2 nM, respectively.
In vivo study	Karenitecin shows maximum growth inhibition of 61% on COLO320 cells and 54% on COLO205 colon cancer cells via i.p. administration of 1 mg/kg in mice. Karenitecin (1.0 mg/kg daily × 5 i.p.) significantly suppresses growth inhibition both in the parental Pgp-negative xenografts and in the Pgp-positive xenografts.

Last Update：2024-01-02 23:10:35

Product Name: Karenitecin Visit Supplier Webpage Request for quotation
CAS: 203923-89-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Karenitecin Visit Supplier Webpage Request for quotation
CAS: 203923-89-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

203923-89-1

203923-89-1 Request for Quotation