205445-55-2

205445-55-2 - Names and Identifiers

Name	N-(tert-butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine
Synonyms	BOC-D-PHE(F)3-OH BOC-D-PHE(M,P-F3)-OH BOC-D-PHE(3,4,5-F 3)-OH BOC-D-PHE(3,4,5-TRIFLUORO)-OH BOC-D-3,4,5-TRIFLUOROPHENYLALANINE Boc-D-3,4,5-Trifluorophenylalanine BOC-3,4,5-TRIFLUORO-D-PHENYLALANINE N-(T-BUTOXYCARBONYL)-3,4,5-TRIFLUORO-D-PHENYLALANINE N-(tert-butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine N-ALPHA-T-BUTOXYCARBONYL-D-(3,4,5-TRIFLUOROPHENYL)ALANINE
CAS	205445-55-2
InChI	InChI=1/C14H16F3NO4/c1-14(2,3)22-13(21)18-10(12(19)20)6-7-4-8(15)11(17)9(16)5-7/h4-5,10H,6H2,1-3H3,(H,18,21)(H,19,20)/t10-/m1/s1

205445-55-2 - Physico-chemical Properties

Molecular Formula	C14H16F3NO4
Molar Mass	319.28
Density	1.323±0.06 g/cm3(Predicted)
Boling Point	424.4±45.0 °C(Predicted)
Flash Point	210.5°C
Vapor Presure	5.83E-08mmHg at 25°C
pKa	3.71±0.10(Predicted)
Storage Condition	Keep Cold
Refractive Index	1.495

205445-55-2 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Harmful/Irritant/Keep Cold
Hazard Class	IRRITANT

205445-55-2 - Introduction

N-(tert-butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine is an organic compound with the following properties:

1. Appearance: White crystalline solid.
2. Solubility: soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane.
3. Melting Point: about 85-86 ° C.

N-(tert-butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine is widely used in chemical synthesis and is used as a starting material for polypeptide synthesis. Some of its main uses include:

1. Polypeptide synthesis: as a starting material with a trifluorophenylalanine residue in the synthetic polypeptide.
2. Drug development: for the synthesis of biologically active compounds and drugs.
3. Chemical Research: as a reagent and intermediate of organic synthesis reaction.

The preparation method of N-(tert-butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine is generally carried out by the following steps:

1. Benzoyl chloride and [[dimethylaminomethyl] tetrafluoroborate (Boc-NHCH2BF3) are reacted in a two-phase system to give the precursor product of N-(tert-butoxycarbonyl)-3,4,5-trifluoro-D-phenylalanine.
2. The product was purified by high performance liquid chromatography (HPLC) or column chromatography.

However, during Operation and storage, N-(tert-butoxycarbonyl)-3,4, 5-trifluororo-d-phenylalanine requires the following safety information:

1. This compound may be irritating to the eyes, skin and mucous membranes, so appropriate personal protective equipment such as gloves, goggles and laboratory clothing should be worn during operation.
2. Avoid inhaling dust or solution vapor, and ensure that the operation is carried out in a well-ventilated place.
3. Store in a dry, cool and well-ventilated place, away from fire and oxidizing agents.
4. In use, strictly abide by the relevant safety procedures and operating guidelines.

Last Update：2024-04-09 21:21:28