Molecular Formula | C15H18O2 |
Molar Mass | 230.3 |
Density | 1.022±0.06 g/cm3(Predicted) |
Melting Point | 83-84℃ |
Boling Point | 89.5-90.5 °C |
Solubility | Soluble in methanol, chloroform, ethyl acetate. |
Appearance | White crystal |
Storage Condition | 2-8℃ |
MDL | MFCD21333249 |
Physical and Chemical Properties | derived from curcuma |
Reference Show more | 1. Jiang Ying Miyu Shuai Wang Xiaoqin, etc. Pro-apoptotic effect of furanodione on colorectal cancer RKO cells [J]. Chinese Journal of new drugs and clinical medicine, 2018, 37(4): 223-228. 2. Hao Min, Lu, Lin, Mao, Chun, Qin, et al. UPLC fingerprint and multi-component content determination of three processed rhizome products of Curcuma wenyujin [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 43(11). 3. Yu Mengting, Tong Huang Jin, Mao Chunqin, Sudan, Yin Fangzhou, Fei Cheng Hao, Wang Meng, Ji De, Lu Jiulin. Quality identification of different Rhizoma curcumae decoction pieces based on color quantification and main component content [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(06):1393-1400. 4. Jiang, Ying, Xiaoqin Wang, and Dao De Hu. "Furanodienone agents G0/G1, arrest, and causes, the ROS/MAPKs-mediated, caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo." Cell Death & Disease 8.5 (2017): e2815-e 5. Wang, Xiaoqin, Ying Jiang, and Daode Hu. "Antiproliferative activity of Curcuma phaeocaulis Valeton extract using ultrasonic assistance and response surface methodology." Preparative Biochemistry and Biotechnology 47.1 (2017): 19-31. 6. [IF=6.304] Jiang Ying et al."Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo."Cell Death Dis. 2017 May;8(5):e2815-e2815 |
biological activity | Furanodienone is one of the main bioactive components derived from Rhizoma Curcumae. Furanodienone induces apoptosis. |
Cell Line: | RKO and HT-29 cells RKO and HT-29 cells |
Concentration: | 0 μM; 50 μM; 100 μM; 150 μM 0 μM; 75 μM; 150 μM |
Incubation Time: | 24 hours 24 hours |
Result: | Increased caspase-9 and -3. Induced apoptosis of colorectal cells (RKO and HT-29). |
Use | for content determination/identification/pharmacological experiments. |