Name | Momordin Ic |
Synonyms | MOMORDINIC Momordinic Momordin 1c MorModin Ic Momordin Ic Ic Momordin Ic 28-norolean-12-en-3-yl 3-O-β-D-xylopyranosyl- β-D-Glucopyranosiduronic acid, (3β)-17-carboxy- 28-Noroleanane,β-D-glucopyranosiduronic acid deriv olean-12-en-28-oic acid, 3-[(3-O-beta-D-xylopyranosyl-beta-D-glucopyranuronosyl)oxy]-, (3beta)- (3beta)-28-Hydroxy-28-oxoolean-12-en-3-yl 3-O-beta-D-xylopyranosyl-beta-D-glucopyranosiduronic acid |
CAS | 96990-18-0 |
InChI | InChI=1/C41H64O13/c1-36(2)14-16-41(35(49)50)17-15-39(6)20(21(41)18-36)8-9-24-38(5)12-11-25(37(3,4)23(38)10-13-40(24,39)7)52-34-29(46)30(28(45)31(54-34)32(47)48)53-33-27(44)26(43)22(42)19-51-33/h8,21-31,33-34,42-46H,9-19H2,1-7H3,(H,47,48)(H,49,50)/t21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31-,33-,34+,38-,39+,40+,41-/m0/s1 |
Molecular Formula | C41H64O13 |
Molar Mass | 764.94 |
Density | 1.35±0.1 g/cm3(Predicted) |
Melting Point | 238-240 °C |
Boling Point | 886.2±65.0 °C(Predicted) |
Specific Rotation(α) | (c, 1.03 in MeOH)+15.4 |
Flash Point | 263.1°C |
Solubility | Soluble in methanol |
Vapor Presure | 0mmHg at 25°C |
Appearance | Light yellow crystalline powder |
Color | White to Pale Yellow |
pKa | 2.75±0.70(Predicted) |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Refractive Index | 1.605 |
MDL | MFCD11042256 |
Physical and Chemical Properties | Light yellow crystalline powder, soluble in methanol, derived from Kodii. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29389090 |
Reference Show more | 1. Wu Xiaoyan, Fang Lihong, LV Weiqi, etc. Variation of saponin Ⅰ c content in Koji Fuzi and screening of superior germplasm [J]. Chinese Journal of Experimental prescriptions, 2019, 25(06):191-196. 2. [IF = 6.17] Yashi Mi et al."Mordin Ic couples apoptosis with autophagy in human heartplasstoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways."Free Radical Bio Med. 2016 Jan;90:230 3. [IF=2.629] Luo Meijunzi et al."Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway."Evid-Based Compl Alt. 2021;2021:5522164 |
biological activity | Momordin Ic is the main saponin component of dogwood and has anti-cancer activity. Momordin Ic regulates mitochondrial dysfunction through oxidative stress and induces apoptosis. |
chemical properties | light yellow crystalline powder, soluble in methanol, derived from konefin. |
use | konosin Ic has the effects of clearing away heat and dampness, dispelling wind and relieving itching, and has the effects of anti-itching, anti-inflammatory and anti-allergic. used for content determination/identification/pharmacological experiments and other pharmacological effects: it has the effects of clearing heat and dampness, dispelling wind and relieving itching. Momordin Ic is the main effective ingredient of its anti-itching, anti-inflammatory and anti-allergic effects. |