3'-叠氮-2',3'-双脱氧尿苷
3'-azido-2',3'-dideoxyuridine
CAS: 84472-85-5
Molecular Formula: C9H11N5O4
3'-叠氮-2',3'-双脱氧尿苷 - Names and Identifiers
| Name | 3'-azido-2',3'-dideoxyuridine |
| Synonyms | CS-87 AzddU 3'-Az-ddU Navuridine 3'-AZIDO-2',3'-DIDEOXYURIDINE 2',3'-Dideoxy-3'-azidouridine 3'-azido-2',3'-dideoxyuridine 3'-Azido-2',3'-dideoxy-D-uridine 3'-Azido-2',3'-dideoxy-1-beta-D-erythro-pentofuranosyluracil 1-(2,3-dideoxy-3-triaza-1,2-dien-2-ium-1-ylpentofuranosyl)pyrimidine-2,4(1H,3H)-dione |
| CAS | 84472-85-5 |
| InChI | InChI=1/C9H11N5O4/c10-13-12-5-3-8(18-6(5)4-15)14-2-1-7(16)11-9(14)17/h1-2,5-6,8,15H,3-4H2,(H,11,16,17)/t5-,6+,8+/m0/s1 |
3'-叠氮-2',3'-双脱氧尿苷 - Physico-chemical Properties
| Molecular Formula | C9H11N5O4 |
| Molar Mass | 253.21 |
| Melting Point | 166-167℃ |
| Solubility | DMSO (Slightly), Methanol (Very Slightly) |
| Appearance | Solid |
| Color | White |
| Storage Condition | −20°C |
3'-叠氮-2',3'-双脱氧尿苷 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29349990 |
3'-叠氮-2',3'-双脱氧尿苷 - Introduction
3 '-azido-2',3 '-dideoxyuridine is a chemical, also known as 3'-azido-2 ',3'-tandem deoxyuridine or 3 '-azidoguanosine. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Chemical formula: C9H12N6O3
-Molecular weight: 248.23g/mol
-Appearance: White crystalline solid
-melting point: 213-214 degrees Celsius
-Solubility: Slightly soluble in water, soluble in methanol and ethanol
Use:
3 '-azido-2',3 '-dideoxyuridine are mainly used in the field of biomedical research, especially in the design of nucleic acid drugs and the treatment of viral infections. It is used as a precursor to antiviral drugs, for example in anti-AIDS virus (HIV) research.
Preparation Method:
The preparation of 3 '-azido-2',3 '-dideoxyuridine usually takes 2',3 '-dideoxyuridine as the starting material and obtains the final product through a series of chemical reactions. The specific preparation method may include the synthetic reaction of 2 ',3'-dideoxyuridine with iminotrifluoromethanesulfonic acid to obtain 3 '-imino-2',3 '-dideoxyuridine, and then obtaining the final product through the reaction of sodium cyanide and catechol's reagent.
Safety Information:
- 3 '-azido-2',3 '-dideoxyuridine is a toxic substance and should be avoided by skin contact, inhalation or ingestion.
-Take care to wear appropriate personal protective equipment such as gloves, goggles and laboratory goggles during use and handling.
-When used in a laboratory environment, follow relevant safety procedures and laboratory safety guidelines.
-When disposing of waste, it should be disposed of in accordance with local regulations to avoid pollution to the environment.
Nature:
-Chemical formula: C9H12N6O3
-Molecular weight: 248.23g/mol
-Appearance: White crystalline solid
-melting point: 213-214 degrees Celsius
-Solubility: Slightly soluble in water, soluble in methanol and ethanol
Use:
3 '-azido-2',3 '-dideoxyuridine are mainly used in the field of biomedical research, especially in the design of nucleic acid drugs and the treatment of viral infections. It is used as a precursor to antiviral drugs, for example in anti-AIDS virus (HIV) research.
Preparation Method:
The preparation of 3 '-azido-2',3 '-dideoxyuridine usually takes 2',3 '-dideoxyuridine as the starting material and obtains the final product through a series of chemical reactions. The specific preparation method may include the synthetic reaction of 2 ',3'-dideoxyuridine with iminotrifluoromethanesulfonic acid to obtain 3 '-imino-2',3 '-dideoxyuridine, and then obtaining the final product through the reaction of sodium cyanide and catechol's reagent.
Safety Information:
- 3 '-azido-2',3 '-dideoxyuridine is a toxic substance and should be avoided by skin contact, inhalation or ingestion.
-Take care to wear appropriate personal protective equipment such as gloves, goggles and laboratory goggles during use and handling.
-When used in a laboratory environment, follow relevant safety procedures and laboratory safety guidelines.
-When disposing of waste, it should be disposed of in accordance with local regulations to avoid pollution to the environment.
Last Update：2024-04-09 19:05:52
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View History
3'-叠氮-2',3'-双脱氧尿苷
2-(烯丙基二甲基甲硅烷基)吡啶
DI-TERT-BUTYL NITROXIDE
6-肼基烟酸琥珀酰亚胺酯盐酸盐
噻唑-5-基甲胺二盐酸盐
O-BETA-D-GLUCORONOSYL-NAPHTHOL AS-BI
Joint adhesive bracket
Benzoic acid, 4-hydroxy-3-iodo-, 1-methylethyl ester
全氟辛烷磺酸 四乙基铵盐
4-甲基氨基甲基苯基硼酸
2-(烯丙基二甲基甲硅烷基)吡啶
DI-TERT-BUTYL NITROXIDE
6-肼基烟酸琥珀酰亚胺酯盐酸盐
噻唑-5-基甲胺二盐酸盐
O-BETA-D-GLUCORONOSYL-NAPHTHOL AS-BI
Joint adhesive bracket
Benzoic acid, 4-hydroxy-3-iodo-, 1-methylethyl ester
全氟辛烷磺酸 四乙基铵盐
4-甲基氨基甲基苯基硼酸