3,3',4',5,6,7,8-Heptamethoxyflavone

3,3',4',5,6,7,8-Heptamethoxyflavone - Names and Identifiers

Name	3,5,6,7,8,3',4'-heptemthoxyflavone
Synonyms	NSC 618928 3-Methoxynobiletin 5,6,7,8,3,4-hepteMthoxyflavone 3,5,6,7,8,3',4'-heptemthoxyflavone 3,5,6,7,8,3',4'-hepteMthoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone 3',4',3,5,6,7,8-Heptamethoxyflavone 2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-chromen-4-one 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-
CAS	1178-24-1

3,3',4',5,6,7,8-Heptamethoxyflavone - Physico-chemical Properties

Molecular Formula	C22H24O9
Molar Mass	432.42
Density	1.31±0.1 g/cm3(Predicted)
Melting Point	129-131 °C
Boling Point	618.7±55.0 °C(Predicted)
Solubility	Almost insoluble (0.052g/L) (25°C),
Appearance	Pale yellow powder
Storage Condition	2-8℃
MDL	MFCD00210513
Physical and Chemical Properties	Pale yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Fructus Aurantii Immaturus.

3,3',4',5,6,7,8-Heptamethoxyflavone - Reference

Reference

1. Gao Xi-Mei, Wang Xiao, Feng, Zhou Bing-Qian, et al. Establishment of HPLC fingerprint of pericarpium citri reticulatae under multi-wavelength conditions and "one test and multiple evaluation" method [J]. Chinese herbal medicine, 42 Vol. 11 page 2598-2602 MEDLINE microscopic PKU 2020.
2. Zhou Qi, talk about anqun, Yi Xin, etc. Identification of broad-peel orange juice from orange juice based on characteristic components of citrus juice polymethoxyflavone [J]. Food and Fermentation Industry, 2019, 45:227-233.
3. Simultaneous determination of 12 kinds of methoxyflavonoids and coumarins in citrus juice by Li Guijie, Tan Xiang, Wang Hua, Wu Houyan, Russell ROUSEFF.HPLC-DAD-FLD [J]. Food Science, 2017, 38(20):112-118.
4. Feng, Konglong, et al. "Hepatic lipidomics analysis reveals the antiobesity and cholesterol-lowering effects of tangeretin in high-fat diet-fed rats." Journal of agricultural and food chemistry 68.22 (2020): 6142-6153.https://doi.org/10.1021/acs.jafc.0c017
5. Wang, Peng, et al. "Chemical and genetic discrimination of commercial Guangchenpi (Citrus reticulata 'Chachi') by using UPLC-QTOF-MS/MS based metabolomics and DNA barcoding approaches." RSC advances 9.40 (2019): 23373-23381.https://doi.org/10.1039/C9RA0374
6. [IF=5.279] Wei-Lun Hung et al."A Targeted Mass Spectrometry-Based Metabolomics Approach toward the Understanding of Host Responses to Huanglongbing Disease."J Agr Food Chem. 2018;66(40):10651-10661
7. [IF=7.132] Li Yang et al."Supercritical extraction and antioxidant activity of major ingredients in Puerariae lobatae root, Pinus massoniana needle, Citrus reticulata peel and their mixture."J Co2 Util. 2021 Jun;48:101518
8. [IF=5.279] Linhua Huang et al."Effects of Scion/Rootstock Combination on Flavor Quality of Orange Juice from Huanglongbing (HLB)-Affected Trees: A Two-Year Study of the Targeted Metabolomics."J Agr Food Chem. 2020;68(10):3286-3296
9. [IF=5.279] Konglong Feng et al."Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats."J Agr Food Chem. 2020;68(22):6142-6153
10. [IF=4.162] Guijie Li et al."Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil."Drug Des Dev Ther. 2021; 15: 937-947
11. [IF=2.629] Mu Qixuan et al."Study on Closely Related Citrus CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis."Evid-Based Compl Alt. 2022;2022:1106353
12. [IF=6.576] Mei Yang et al."Chemical Variation of Chenpi (Citrus Peels) and Corresponding Correlated Bioactive Compounds by LC-MS Metabolomics and Multibioassay Analysis."Front Nutr. 2022; 9: 825381
13. [IF=4.35] Qian Yu et al."Aged Pericarpium Citri Reticulatae 'Chachi' Attenuates Oxidative Damage Induced by tert-Butyl Hydroperoxide (t-BHP) in HepG2 Cells."Foods. 2022 Jan;11(3):273

3,3',4',5,6,7,8-Heptamethoxyflavone - Reference Information

biological activity	3,5,6,7,8,3 ',4'-Heptemthoxyflavone is a flavone in mandarin peel, which has anti-tumor initial activity and anti-neuroinflammatory activity. 3,5,6,7,8,3 ',4'-Heptemthoxyflavone can inhibit the activity of collagenase and increase the content of type I procollagen in human dermal fibroblasts (HDFn) cells. 3,5,6,7,8,3 ',4'-Heptemthoxyflavone can induce brain-derived neurotrophic factor (BDNF) expression through cAMP/ERK/CREB signal and reduce phosphodiesterase activity in C6 cells.
chemical properties	light yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from bitter orange.
use	used for content determination/identification/pharmacological experiments, etc.

Last Update：2024-04-09 21:31:57

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