Name | 3,4,5-Trimethoxybenzyl alcohol |
Synonyms | AI3-38651 RARECHEM AL BD 0063 3,4,5-Trimethyxybencylalcohol 3,4,5-TRIMETHOXYBENZYL ALCOHOL 3,4,5-Trimethoxybenzyl alcohol 3,4,5-TRIMETHOXYBENZENEMETHANOL (3,4,5-TRIMETHOXYPHENYL)METHANOL (3,4,5-trimethoxyphenyl)methanol 3,4,5-Trimethoxybenzylic alcohol Benzyl alcohol, 3,4,5-trimethoxy- Benzenemethanol, 3,4,5-trimethoxy- |
CAS | 3840-31-1 |
EINECS | 223-331-4 |
InChI | InChI=1/C10H14O4/c1-12-8-4-7(6-11)5-9(13-2)10(8)14-3/h4-5,11H,6H2,1-3H3 |
Molecular Formula | C10H14O4 |
Molar Mass | 198.22 |
Density | 1.233g/mLat 25°C(lit.) |
Melting Point | 3°C |
Boling Point | 228°C25mm Hg(lit.) |
Flash Point | >230°F |
Solubility | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate |
Vapor Presure | 1.75E-05mmHg at 25°C |
Appearance | Oil |
Specific Gravity | 1.20 |
Color | Yellow |
BRN | 2104523 |
pKa | 13.99±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | n20/D 1.543(lit.) |
MDL | MFCD00004639 |
Use | Used as an intermediate in organic synthesis |
Hazard Symbols | Xi - Irritant![]() |
Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
Hazard Class | IRRITANT |
application | 3,4,5-trimethoxybenzyl alcohol is a commonly used pharmaceutical intermediate, which can be used to synthesize polyhydroxystilbene compounds with anti-tumor and anti-aging activities. |
preparation | 3,4,5-trimethoxybenzaldehyde 2.729g and sodium borohydride 0.459g are dissolved in 20ml of methanol, stirred for 30min at room temperature, adjusted to pH 8-9 with dilute hydrochloric acid, extracted with chloroform (10ml × 2), after the organic phase is combined, it is washed with water (10ml × 2), dried by anhydrous magnesium sulfate and filtered, and the filtrate is evaporated to remove the solvent to obtain 2.61g of oily 3,4, 5-trimethoxybenzyl alcohol with a yield of 95%. |
Use | Used as an intermediate in organic synthesis Organic intermediate. |
NIST chemical information | information provided by: webbook.nist.gov (external link) |