Molecular Formula | C5H3Cl3NNaO |
Molar Mass | 222.42 |
Density | 1426[at 20℃] |
Boling Point | 325°C at 760 mmHg |
Flash Point | 150.4°C |
Water Solubility | 2.5g/L at 20℃ |
Solubility | Methanol (Slightly) |
Vapor Presure | 0Pa at 25℃ |
Appearance | Solid |
Color | White |
Storage Condition | Sealed in dry,Room Temperature |
Physical and Chemical Properties | The Pure product is an off-white solid, slightly soluble in water, with a saturated solution concentration of about 0.5% in ice water and about 20% in boiling water. Soluble in acetonitrile, methanol, ethanol and other organic solvents, under acidic conditions into 3,5, 6-trichloropyridin-2-ol (melting point 169~171 ℃). off-white powder. There are two routes to the industrial synthesis of trichloropyridinol. |
Use | 2-hydroxy-3, 5, 6-trichloropyridine, also known as trichloropyridinol, is an intermediate of chlorpyrifos and chlorpyrifos methyl, and its sodium salt is used industrially. |
LogP | -0.64 at 22.4℃ |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Use | Used to produce high-efficiency and low-residue insecticide and acaricide chlorpyrifos, chlorpyrifos methyl, etc. 2-Hydroxy -3,5, 6-Trichloropyridine, also known as trichloropyridine, is an intermediate of organophosphorus insecticides chlorpyrifos and chlorpyrifos methyl, and its sodium salt is used in industry. |
Production method | There are two routes for the industrial synthesis of trichloropyridinol. (1) Chlorinate pyridine to make 2,3,5,6-tetrachloropyridine, and then base the tetrachloropyridine with sodium hydroxide to make trichloropyridine sodium salt. (2) Reaction with trichloroacetyl chloride and acrylonitrile to obtain trichloropyridinol, and then alkaline hydrolysis to obtain its sodium salt. 280kg of trichloroacetyl chloride, excess acrylonitrile and appropriate amount of solvent and catalyst were put into 1500L enamel reactor to heat up the reflux reaction and control the end point by gas chromatography. After the acid chloride is converted (about 14h), the reaction can be stopped, and then the reactants are pumped into the distillation kettle, and the solution is decompressed. The solvent removed is recovered and applied. After the solvent is removed, the residue is pumped into the alkalization kettle, and 30% NaOH is slowly added dropwise for alkalization, and the temperature is controlled at 20~40 ℃. Filter to obtain trichloropyridinol sodium salt wet product, which can directly enter the next reaction. Starting from the reaction process, the reaction can also be controlled in three steps. This can effectively control the generation of by-products and improve the reaction yield and product quality. At present, both processes can be produced, and when pyridine is used as raw material, the reaction process is highly corrosive, but the product quality is good. The wet trichloropyridinol sodium is a gray-yellow solid. |