3,5-Bis(trifluoromethyl)-benzyl amine

3,5-Bis(trifluoromethyl)-benzyl amine - Names and Identifiers

Name	3,5-bis(trifluoromethyl)benzylamine
Synonyms	MBT-BYM TIMTEC-BB SBB000829 RARECHEM AL BW 0137 3,5-DI(TRIFLUOROMETHYL)BENZYLAMINE 1-(2,4-difluorophenyl)propan-1-one 3,5-Bis(TrifluroMethyl)BenzylAmine 3,5-BIS(TRIFLUOROMETHYL)BENZYLAMINE 3,5-bis(trifluoromethyl)benzylamine 3,5-Bis(trifluoromethyl)-benzyl amine [3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHANAMINE [3,5-bis(trifluoromethyl)phenyl]methanaminium 1-[3,5-bis(trifluoromethyl)phenyl]methanamine
CAS	85068-29-7
EINECS	285-290-9
InChI	InChI=1/C9H7F6N/c10-8(11,12)6-1-5(4-16)2-7(3-6)9(13,14)15/h1-3H,4,16H2/p+1

3,5-Bis(trifluoromethyl)-benzyl amine - Physico-chemical Properties

Molecular Formula	C9H7F6N
Molar Mass	243.15
Density	1.3653 (estimate)
Melting Point	50-55°C(lit.)
Boling Point	82-84 °C (15 mmHg)
Flash Point	173°F
Solubility	soluble in Methanol
Vapor Presure	1.86mmHg at 25°C
Appearance	Crystalline Mass, Powder, Crystals and/or Chunks
Color	White to beige
BRN	7209267
pKa	8.32±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Sensitive	Air Sensitive
MDL	MFCD00009909

3,5-Bis(trifluoromethyl)-benzyl amine - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R34 - Causes burns R21/22 - Harmful in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3259 8/PG 2
WGK Germany	3
FLUKA BRAND F CODES	10-34
HS Code	29214990
Hazard Note	Corrosive
Hazard Class	8
Packing Group	III

3,5-Bis(trifluoromethyl)-benzyl amine - Introduction

3,5-bis(trifluoromethyl)benzylamine is an organic compound with the chemical formula C9H7F6N. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to light yellow liquid
-Solubility: Soluble in most organic solvents, such as ethanol, ether and dichloromethane
-Melting point:-53°C
-Boiling Point: 154-156°C
-Density: 1.47 g/mL
-Refractive Index: 1.412

Use:
- 3,5-bis(trifluoromethyl)benzylamine is commonly used as a reagent in organic synthesis to introduce trifluoromethyl groups into molecules to change molecular properties or increase the activity of compounds.
-It can be used in the field of drug synthesis, pesticide synthesis and material science.

Preparation Method:
-The preparation of 3,5-bis(trifluoromethyl)benzylamine is generally carried out by the following steps:
1. Mix 3,5-difluoromethylbenzyl alcohol and aminomethane (methylamine) in an appropriate molar ratio.
2. The reaction mixture is heated and stirred in a suitable solvent.
3. Control the reaction temperature to be carried out within an appropriate range, generally from room temperature to the boiling point of the reaction solvent.
4. The resulting product is purified by crystallization and/or extraction.

Safety Information:
- 3,5-bis(trifluoromethyl)benzylamine is an organic compound that is irritating and corrosive.
-Wear appropriate personal protective equipment such as gloves, glasses and protective clothing during use and operation.
-Avoid contact with skin, eyes and respiratory tract, and prevent inhalation of gas, vapor, mist or dust.
-Observe local regulations and safe practices when storing and handling the compound safely.

Last Update：2024-04-09 02:00:48