Molecular Formula | C8H11N5S2 |
Molar Mass | 241.34 |
Density | 1.49±0.1 g/cm3(Predicted) |
Melting Point | 128-132°C(lit.) |
Boling Point | 459.7±55.0 °C(Predicted) |
Flash Point | 227.4°C |
Vapor Presure | 2.24E-08mmHg at 25°C |
pKa | 8.51±0.70(Predicted) |
Storage Condition | -20°C Freezer |
Refractive Index | 1.727 |
Physical and Chemical Properties | Crystalline compound. Melting point 126-128 °c (126-129 °c). |
Hazard Symbols | Xn - Harmful![]() |
Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact |
Safety Description | S22 - Do not breathe dust. S24 - Avoid contact with skin. S37 - Wear suitable gloves. |
WGK Germany | 1 |
Application | 3-(2-guanidino-thiazol-4-ylmethylthio)-Propionitrile can be used as an intermediate of famotidine, mainly used in pharmaceutical research and development process and chemical production process. |
Use | an intermediate of famotidine. |
production method | cyclization of carbazylthiourea with 1, 3-dichloroacetone, this product was prepared by forming 3-((2-guanidin-4-thiazolyl) methyl) isothiourea dihydrochloride and reacting with β-chloropropionitrile. |