3-氯-4-氟苯基溴化镁

3-氯-4-氟苯基溴化镁 - Names and Identifiers

Name	bromo(3-chloro-4-fluorophenyl)magnesium
Synonyms	bromo(3-chloro-4-fluorophenyl)magnesium magnesium,1-chloro-2-fluorobenzene-5-ide,bromide 3-chloro-4-fluorophenylmagnesium bromide solution 3-Chloro-4-fluorophenylmagnesium bromide, 0.50 M in THF 3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 in THF 3-Chloro-4-fluorophenylmagnesium bromide solution 0.5 M in THF 3-Chloro-4-fluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal
CAS	413589-34-1
InChI	InChI=1/C6H3ClF.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h2-4H;1H;/q;;+1/p-1/rC6H3BrClFMg/c7-10-4-1-2-6(9)5(8)3-4/h1-3H

3-氯-4-氟苯基溴化镁 - Physico-chemical Properties

Molecular Formula	C6H3BrClFMg
Molar Mass	233.7484232
Density	0.966g/mLat 25°C
Boling Point	65°C
Flash Point	1°F
Storage Condition	2-8°C

3-氯-4-氟苯基溴化镁 - Risk and Safety

Risk Codes	R11 - Highly Flammable R14 - Reacts violently with water R19 - May form explosive peroxides R22 - Harmful if swallowed R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R37 - Irritating to the respiratory system
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2924 3/PG 2
WGK Germany	1
HS Code	29310099

3-氯-4-氟苯基溴化镁 - Reference Information

Application

3-chloro-4-fluorophenyl magnesium bromide can be used as an intermediate in pharmaceutical synthesis, such as the preparation of pyrrolidine derivatives such as (2R,5S)-1-(tert-butoxycarbonyl)-5-(3-chloro-4-fluorophenyl) pyrrolidine-2-carboxylate, the compound has peptide calcitonin gene-related peptide (CGRP) receptor antagonism and can be used to treat various diseases associated with CGRP receptors.

Preparation method

Add trace iodine to the mixture of magnesium (434mg) and THF(2mL) under argon atmosphere. After the mixture is heated to 60°C, a solution of THF(6.5mL) of 4-bromo-2-chloro-1-fluorobenzene (3.58g) is added dropwise (the temperature is maintained at 65°C during dropwise addition). The mixture was stirred at 60°C for 30 minutes and then cooled to room temperature to obtain 3-chloro-4-fluorophenyl magnesium bromide.

Last Update：2024-04-10 22:29:15