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3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

Azelnidipine

CAS: 123524-52-7

Molecular Formula: C33H34N4O6

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3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate - Names and Identifiers

Name Azelnidipine
Synonyms CS 905
CCRIS 8650
Azelidipine
AZELNIDIPINE
Azenildipine
Azelnidipine
AZELINIDIPINE
UNII-PV23P19YUG
AzelnidipineC33H34N406
3-[1-(diphenylmethyl)azetidin-3-yl] 5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-[1-(Diphenylmethyl)-3-azetidinyl]-5-(1-methylethyl-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
CS-905, RS-9054, 2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
CAS 123524-52-7
EINECS 634-143-0
InChI InChI=1/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
InChIKey ZKFQEACEUNWPMT-UHFFFAOYSA-N

3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate - Physico-chemical Properties

Molecular FormulaC33H34N4O6
Molar Mass582.65
Density1.33±0.1 g/cm3(Predicted)
Melting Point120-126°C
Boling Point709.3±60.0 °C(Predicted)
Flash Point382.8°C
Solubility DMSO: >10mg/mL
Vapor Presure5.74E-20mmHg at 25°C
Appearancepowder
ColorYellow
Merck14,907
pKa7.89(at 25℃)
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
Refractive Index1.658
MDLMFCD00865803
UseAzelnidipine is a dihydropyridine calcium channel blocker.
In vitro studyAzelnidipine is a newly developed long-acting calcium channel blocker with unique pharmacological properties, such as slowing the heartbeat and high affinity for vascular tissue, these properties make it different from other calcium channel blockers, so Azelnidipine is a new generation of calcium channel blockers that can be used to treat high blood pressure, regardless of whether the patient is at risk of ischemic heart disease. Because of its high fat solubility, it can still remain in the blood vessel wall after it is cleared from the blood.

3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R41 - Risk of serious damage to eyes
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
WGK Germany3
RTECSUS7968332
ToxicityLD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally

3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.716 ml8.581 ml17.163 ml
5 mM0.343 ml1.716 ml3.433 ml
10 mM0.172 ml0.858 ml1.716 ml
5 mM0.034 ml0.172 ml0.343 ml
Last Update：2024-01-02 23:10:35
3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
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Hefei TNJ Chemical Industry Co.,Ltd.
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CAS: 123524-52-7
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Azelnidipine Request for quotation
CAS: 123524-52-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Azelnidipine Visit Supplier Webpage Request for quotation
CAS: 123524-52-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
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