3-(2-氟苯基)异恶唑-5-甲醛

3-(2-氟苯基)异恶唑-5-甲醛 - Names and Identifiers

Name	3-(2-fluorophenyl)isoxazole-5-carbaldehyde
Synonyms	3-(2-Fluorphenyl)-1,2-oxazol-5-carbaldehyd 3-(2-fluorophenyl)isoxazole-5-carbaldehyde 3-(2-Fluorophenyl)-5-isoxazolecarboxaldehyde 3-(2-FLUORO-PHENYL)-ISOXAZOLE-5-CARBALDEHYDE 3-(2-Fluorophenyl)-1,2-oxazole-5-carbaldehyde 3-(2-fluorophenyl)-1,2-oxazole-5-carbaldehyde 5-Isoxazolecarboxaldehyde, 3-(2-fluorophenyl)- 5-isoxazolecarboxaldehyde, 3-(2-fluorophenyl)-
CAS	808740-52-5
InChI	InChI=1/C10H6FNO2/c11-9-4-2-1-3-8(9)10-5-7(6-13)14-12-10/h1-6H

3-(2-氟苯基)异恶唑-5-甲醛 - Physico-chemical Properties

Molecular Formula	C10H6FNO2
Molar Mass	191.16
Density	1.303g/cm³
Boling Point	350.2°C at 760 mmHg
Flash Point	165.6°C
Vapor Presure	4.45E-05mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.568

3-(2-氟苯基)异恶唑-5-甲醛 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

3-(2-氟苯基)异恶唑-5-甲醛 - Introduction

3-(2-fluorophenyl)isoxazole-5-carbaldehyde is an organic compound whose chemical formula is C10H6FNO2. The following is a description of the properties, uses, preparation and safety information of this compound:

Nature:
-Appearance: Colorless crystalline solid
-Solubility: Soluble in organic solvents such as chloroform, dichloromethane
-Melting point: about 113-115°C
-Molecular weight: about 193.16g/mol

Use:
- 3-(2-fluorophenyl)isoxazole-5-carbaldehyde can be used as an important organic synthesis intermediate. It can be used to synthesize other organic compounds, such as drugs, pesticides, dyes, etc.
-It has a wide range of applications in medicinal chemistry, such as the synthesis of antiepileptic drugs.
-It can also be used as an intermediate for organic light-emitting diode (OLED) materials.

Preparation Method:
The preparation method of 3-(2-fluorophenyl)isoxazole-5-carbaldehyde is relatively complicated and involves multi-step reactions. A common preparation method is as follows:
1. 2-bromomethylbenzene is obtained by reacting methyl bromide with benzene under alkaline conditions.
2.2-Bromomethylbenzene is reacted with sodium nitrite to obtain 2-nitrosomethylbenzene.
3.2-nitrosomethylbenzene is reacted with sodium cyanide to obtain 2-cyanomethylbenzene.
4.2-cyanomethylbenzene reacts with sodium fluoride, and after dehydration, acidification and other steps, 3-(2-fluorophenyl)isoxazole-5-carbaldehyde is obtained.

Safety Information:
The specific safety information for the -3-(2-fluorophenyl)isoxazole-5-carbaldehyde varies by manufacturer and application. In use, should follow the relevant safety procedures, such as wearing appropriate protective equipment, avoid inhalation, contact with the skin or into the eyes.
-This compound may be toxic or irritating to the human body, so use caution when handling it.
-Observe local laws and regulations when storing and handling. If you need to know more about its safety and operational details, it is recommended to consult chemical information or relevant professionals.

Last Update：2024-04-09 20:49:11