3-(4-FLUOROPHENYL)-INDOLE

3-(4-FLUOROPHENYL)-INDOLE - Names and Identifiers

Name	3-(4-Fluoro-phenyl)-1H-indole
Synonyms	3-(4-FLUOROPHENYL)-INDOLE 3-(4-Fluorophenyl)-Indole 3-(4-Fluoro-phenyl)-1H-indole 3-(4-FLUORO-PHENYL)-1H-INDOLE 1H-Indole, 3-(4-fluorophenyl)- 3-(4-Fluoro-phenyl)-1H-indole hydrochloride
CAS	101125-32-0
InChI	InChI=1/C14H10FN/c15-11-7-5-10(6-8-11)13-9-16-14-4-2-1-3-12(13)14/h1-9,16H

3-(4-FLUOROPHENYL)-INDOLE - Physico-chemical Properties

Molecular Formula	C14H10FN
Molar Mass	211.23
Density	1.232±0.06 g/cm3(Predicted)
Melting Point	96-98 °C
Boling Point	390.5±25.0 °C(Predicted)
Flash Point	190°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	5.93E-06mmHg at 25°C
Appearance	Solid
Color	Pale Yellow to Light Beige
pKa	16.49±0.30(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.658

3-(4-FLUOROPHENYL)-INDOLE - Introduction

3-(4-fluorophenyl) indole is an organic compound with the chemical formula C14H9FN. Its molecule has a pyrrole ring and a benzene ring, in which the fluorine atom is connected to the 4-position on the benzene ring.

3-(4-Fluorophenyl) indole is a light yellow solid, stable at room temperature. It is soluble in common organic solvents such as ethanol, dimethyl sulfoxide and chloroform, and is soluble in water at a certain temperature. The compound has high thermal and chemical stability.

3-(4-fluorophenyl) indole has certain application value in the field of medicine and pesticide. It is an important intermediate and can be used in the synthesis of other compounds, such as indole anticancer compounds and antibacterial agents. In addition, the compounds can also be used as starting units for chemical reagents and organic synthesis.

Preparation of 3-(4-fluorophenyl) indole can be obtained by reacting indole with 4-fluoronitrobenzene. First, the indole was dissolved in anhydrous acetic acid and then 4-fluoronitrobenzene was added. The reaction is carried out at an appropriate temperature and generally requires a longer reaction time. Finally, the target product is obtained by hydrolysis and crystallization.

Regarding the safety information of 3-(4-fluorophenyl) indole, it is relatively safe for human health under general conditions. However, care should be taken to prevent contact with the skin and eyes, and to avoid inhaling its dust or gas. Wear protective gloves and safety glasses during handling and use. In addition, it should be stored in a dry, well-ventilated place, away from fire and oxidizing agents. In case of accidental leakage, proper cleaning measures shall be taken. It is recommended to learn more about the safe handling and handling of this compound before use.

Last Update：2024-04-09 21:54:55