3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
UK 383367
CAS: 348622-88-8
Molecular Formula: C15H24N4O4
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide - Names and Identifiers
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide - Physico-chemical Properties
| Molecular Formula | C15H24N4O4 |
| Molar Mass | 324.38 |
| Density | 1.233 |
| Melting Point | 136-138℃ |
| Solubility | DMSO: >30mg/mL |
| Appearance | powder |
| Color | white to off-white |
| pKa | 9.03±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD19690945 |
| Use | UK-383,367 |
| In vitro study | UK-383367 effective penetration of human skin. UK-383367 inhibited collagen deposition with an IC50 of ~ 2 μm. UK-383367 has modest affinity for all PDE-4 subtypes, with IC50 values of 1.8 μm, 1.5 μm, 2.4 μm and 0.9 μm for PDE-4a, PDE-4b, PDE-4c and PDE-4d, respectively. UK-383367 is a weakly acidic compound that is lipophilic. |
| In vivo study | The plasma protein binding values of UK-383367 for rats, dogs and humans were 95%,93% and 94%, respectively. UK-383367 was incubated in rat plasma with a half-life of 49 minutes. UK-383367 at a dose of 2 mg/kg administered intravenously alone in rats with a plasma clearance of 157 μm min |
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.083 ml | 15.414 ml | 30.828 ml |
| 5 mM | 0.617 ml | 3.083 ml | 6.166 ml |
| 10 mM | 0.308 ml | 1.541 ml | 3.083 ml |
| 5 mM | 0.062 ml | 0.308 ml | 0.617 ml |
Last Update：2024-01-02 23:10:35
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide - Reference Information
| biological activity | UK 383367 is a procollagen C- proteinase (procollagen C- terminal protease) inhibitor with IC50 of 44 nM and excellent selectivity for MMPs. |
| target | TargetValue Procollagen C proteinase 44 nM |
| Target | Value |
| Procollagen C proteinase | 44 nM |
| in vitro study | UK-383367 effectively penetrates human skin. UK-383367 inhibits collagen deposition with IC50 of ~ 2 μM. UK-383367 has a moderate affinity for all PDE-4 subtypes, acting on PDE-4a, PDE-4b, PDE-4c and PDE-4d with IC50 of 1.8 μM, 1.5 μM, 2.4 μM and 0.9 μM, respectively. UK-383367 is a weakly acidic compound with lipophilicity. |
| In vivo studies | The plasma protein binding values of UK-383367 on rats, dogs and humans are 95%,93% and 94% respectively. UK-383367 was incubated in rat plasma with a half-life of 49 minutes. UK-383367 rats were treated intravenously at a dose of 2 mg/kg, and the plasma clearance rate was 157 mL min |
Last Update：2024-04-09 21:54:55
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Product Name: UK 383367 Visit Supplier Webpage Request for quotation
CAS: 348622-88-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 348622-88-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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