3-(Piperazin-1-yl)benzoic acid

3-(Piperazin-1-yl)benzoic acid - Names and Identifiers

Name	3-(Piperazin-1-yl)benzoic acid
Synonyms	AKOS BB-5563 CHEMBRDG-BB 4010136 3-(1-Piperazinyl)benzoic acid 3-PIPERAZIN-1-YL-BENZOIC ACID 1-(3-Carboxyphenyl)piperazine 3-(Piperazin-1-yl)benzoic acid Benzoic acid, 3-(1-piperazinyl)-
CAS	446831-28-3
EINECS	256-495-9
InChI	InChI=1/C11H14N2O2/c14-11(15)9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2,(H,14,15)

3-(Piperazin-1-yl)benzoic acid - Physico-chemical Properties

Molecular Formula	C11H14N2O2
Molar Mass	206.24
Density	1.211g/cm³
Boling Point	431.9°C at 760 mmHg
Flash Point	215°C
Vapor Presure	3.16E-08mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	1.58

3-(Piperazin-1-yl)benzoic acid - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Note	Irritant

3-(Piperazin-1-yl)benzoic acid - Introduction

3-(Piperazin-1-yl)benzoic acid, also known as 3-(Piperazin-1-yl)benzoic acid, is an organic compound. Its chemical formula is C11H13N2O2, and its structure contains a benzene ring and a piperazine group. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: 3-(Piperazin-1-yl)benzoic acid is in the form of colorless crystals or white crystalline powder.
-Solubility: It can be dissolved in some organic solvents, such as dimethylthionamide (DMSO) and dimethylformamide (DMF), and is insoluble in water.
-Melting point: The melting point of the compound is 210-213°C.
- pH: 3-(Piperazin-1-yl)benzoic acid The pH value in water is acidic.

Use:
3-(Piperazin-1-yl)benzoic acid is often used as an important intermediate in organic synthesis. It can be used to synthesize other compounds, such as drugs, bioactive compounds and dyes.

Preparation Method:
3-(Piperazin-1-yl)benzoic acid can be synthesized by the reaction of benzoyl chloride and 1-piperazineethylamine. Benzoyl chloride is first reacted with 1-piperazinethanamine under suitable reaction conditions to yield 3-(1-piperazinyl) benzoyl chloride. The resulting 3-(1-piperazinyl) benzoyl chloride is then converted to 3-(Piperazin-1-yl)benzoic acid by hydrolysis.

Safety Information:
The safety of 3-(Piperazin-1-yl)benzoic acid has not been reported in detail. However, as a chemical, general laboratory practices and safety knowledge should be followed, such as avoiding direct contact with skin and eyes, ensuring good ventilation conditions for operation, etc. In addition, during use and storage, the compound should be handled with caution to prevent the risk of fire and explosion. If more detailed safety information is required, refer to the relevant chemical literature or consult a professional.

Last Update：2024-04-09 21:54:55