3-Acetylaminothiophene-2-carboxylic acid

3-Acetylaminothiophene-2-carboxylic acid - Names and Identifiers

Name	3-(acetylamino)thiophene-2-carboxylic acid
Synonyms	3-acetamido-2-thiophenecarboxylic acid 1H-thieno[3,2-d][1,3]oxazine-2,4-dione 3-acetamidothiophene-2-carboxylic acid 3-Acetylaminothiophene-2-carboxylic acid 3-(ACETYLAMINO)THIOPHENE-2-CARBOXYLIC ACID 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLIC ACID 3-(acetylamino)thiophene-2-carboxylic acid 2-Thiophenecarboxylic acid, 3-(acetylamino)-
CAS	50901-18-3
InChI	InChI=1/C7H7NO3S/c1-4(9)8-5-2-3-12-6(5)7(10)11/h2-3H,1H3,(H,8,9)(H,10,11)

3-Acetylaminothiophene-2-carboxylic acid - Physico-chemical Properties

Molecular Formula	C7H7NO3S
Molar Mass	185.2
Density	1.487g/cm³
Melting Point	200 °C
Boling Point	447.5°C at 760 mmHg
Flash Point	224.4°C
Vapor Presure	8.59E-09mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.657

3-Acetylaminothiophene-2-carboxylic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
HS Code	29349990
Hazard Note	Irritant

3-Acetylaminothiophene-2-carboxylic acid - Introduction

3-(acetylamino)thiophene-2-carboxylic acid is an organic compound with the chemical formula C8H7NO3S. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 3-(acetylamino)thiophene-2-carboxylic acid is a colorless to light yellow solid.
-Solubility: Soluble in common organic solvents such as ethanol, dimethylformamide and dichloromethane, insoluble in water.
-Melting point: about 150-153°C.
-Stability: stable, no obvious decomposition at room temperature.

Use:
3-(acetylamino)thiophene-2-carboxylic acid is commonly used in the fields of organic synthesis and pharmaceutical research. As a raw material for organic synthesis, it can be used to synthesize compounds containing thiophene structure. In drug research, the compound can be used as a drug precursor or intermediate, with certain biological activity.

Preparation Method:
3-(acetylamino)thiophene-2-carboxylic acid can be synthesized by the following steps:
1.2-thiophene carboxylic acid is reacted with acid chloride to generate 2-thiophene carboxylic acid.
2. reacting 2-thiophene carboxylic acid with acetic anhydride to obtain 3-(acetylamino)thiophene-2-carboxylic acid.

Safety Information:
There is no special report on the safety of 3-(acetylamino)thiophene-2-carboxylic acid. However, as a general guideline for handling chemical substances, please note the following:
-Wear appropriate protective equipment, such as lab gloves and goggles, when performing experiments.
-Avoid inhaling its dust or generating its vapor, and operate in a well-ventilated place.
-If exposed or inhaled, immediately rinse your skin or eyes with water and seek medical help.
-When storing, keep it in a sealed container, away from combustibles and oxidants.

Overall, 3-(acetylamino)thiophene-2-carboxylic acid poses a lower security risk when used and stored correctly. However, it is necessary to follow laboratory safety procedures in any chemical experiment.

Last Update：2024-04-09 21:32:41