3-BROMO-2-(BROMOMETHYL)PROPANOIC ACID

Name	3-Bromo-2-(bromomethyl)propionic acid
Synonyms	bis(bromomethyl)acetic acid β,β'-dibromoisobutyric acid BETA,BETA'-DIBROMOISOBUTYRIC ACID 3-bromo-2-(bromomethyl)propanoate 3-BROMO-2-(BROMOMETHYL)PROPANOIC ACID 3-Bromo-2-(bromomethyl)propionic acid 3-bromo-2-(bromomethyl)propanoic acid 3-BROMO-2-(BROMOMETHYL)PROPIONIC ACID Propanoic acid, 3-bromo-2-(bromomethyl)- 3-BROMO-2-(BROMOMETHYL)PROPIONIC ACID (KG LEVEL)
CAS	41459-42-1
InChI	InChI=1/C4H6Br2O2/c5-1-3(2-6)4(7)8/h3H,1-2H2,(H,7,8)/p-1

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3261 8/PG 2
WGK Germany	3
FLUKA BRAND F CODES	8
HS Code	29159000
Hazard Class	8
Packing Group	III

NIST chemical information	Information provided by: webbook.nist.gov (external link)
Introduction	3-bromo-2-bromomethylpropionic acid is an organic intermediate that can be made of bis (hydroxymethyl) malonate diethyl ester and hydrogen bromide Preparation by one-step reaction. There are reports that it can be used to prepare Erk inhibitors.
Uses	3-bromo-2-bromomethylpropionic acid is an organic intermediate, and it has been reported in the literature that it can be used to prepare Erk inhibitors.
Preparation	Commercially available diethyl bis (hydroxymethyl) malonate (25g, 0.11 mol) and 48% The mixture of aqueous hydrogen bromide (192 cubic centimeters, 1.70 mol) is heated until the bromoethane liquid starts to evaporate from the mixture, and then vigorously distilled for about 1h. the reaction mixture was refluxed at 140 ℃ for 5 hours. The solution was cooled in an ice bath for 1. 5 hours. The crystals formed are filtered, washed with a small amount of ice-cold water and dried in vacuum. Distill about 80 cm3 filtrate, cool the solution in ice to produce another batch of crystals, wash and dry as mentioned above to obtain 3-bromo-2-bromomethylpropionic acid.

Last Update：2024-04-09 20:49:11