3-Bromomethyl-azetidine-1-carboxylic acid tert-butyl ester
1-Boc-3-(bromomethyl)azetidine
CAS: 253176-93-1
Molecular Formula: C9H16BrNO2
3-Bromomethyl-azetidine-1-carboxylic acid tert-butyl ester - Names and Identifiers
3-Bromomethyl-azetidine-1-carboxylic acid tert-butyl ester - Physico-chemical Properties
| Molecular Formula | C9H16BrNO2 |
| Molar Mass | 250.13 |
| Density | 1.363±0.06 g/cm3(Predicted) |
| Melting Point | 38-40°C |
| Boling Point | 281.2±13.0 °C(Predicted) |
| Water Solubility | Sparingly soluble in water at 25°C, 0.83 g/L. |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Off-White Low-Melting |
| pKa | -2.33±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Light Sensitive |
3-Bromomethyl-azetidine-1-carboxylic acid tert-butyl ester - Risk and Safety
| Hazard Class | IRRITANT |
3-Bromomethyl-azetidine-1-carboxylic acid tert-butyl ester - Introduction
1-Boc-3-(bromomethyl)azetidine is an organic compound with the following properties:
Appearance: Colorless liquid or solid
Molecular formula: C9H17BrN2O2
Molecular weight: 267.15g/mol
The main use of 1-Boc-3-(bromomethyl)azetidine is as a reaction intermediate in organic synthesis. It can be used to synthesize novel organic compounds or drugs. Because of its stability and solubility, it is widely used in the field of drug synthesis.
The method for preparing 1-Boc-3-(bromomethyl)azetidine is as follows:
First, 3-hydrotepropionic acid (N-Boc-3-hydroxypropylamine) is reacted with methyl bromide to produce 3-bromomethylpropionic acid (N-Boc-3-(bromomethyl)propionic acid). The resulting 3-bromomethylpropanoic acid is then reacted with dimethylethylenediamine to give the final product 1-Boc-3-(bromomethyl)azetidine.
Regarding safety information, 1-Boc-3-(bromomethyl)azetidine is a chemical that requires careful handling. It may be irritating and corrosive to the skin and eyes, so avoid contact with skin and eyes when using it. Wear appropriate personal protective equipment such as protective gloves and goggles when operating.
In addition, 1-Boc-3-(bromomethyl)azetidine should be stored in a sealed container, away from fire and oxidizing agents. During storage and handling, ensure good ventilation and follow appropriate safety procedures.
Appearance: Colorless liquid or solid
Molecular formula: C9H17BrN2O2
Molecular weight: 267.15g/mol
The main use of 1-Boc-3-(bromomethyl)azetidine is as a reaction intermediate in organic synthesis. It can be used to synthesize novel organic compounds or drugs. Because of its stability and solubility, it is widely used in the field of drug synthesis.
The method for preparing 1-Boc-3-(bromomethyl)azetidine is as follows:
First, 3-hydrotepropionic acid (N-Boc-3-hydroxypropylamine) is reacted with methyl bromide to produce 3-bromomethylpropionic acid (N-Boc-3-(bromomethyl)propionic acid). The resulting 3-bromomethylpropanoic acid is then reacted with dimethylethylenediamine to give the final product 1-Boc-3-(bromomethyl)azetidine.
Regarding safety information, 1-Boc-3-(bromomethyl)azetidine is a chemical that requires careful handling. It may be irritating and corrosive to the skin and eyes, so avoid contact with skin and eyes when using it. Wear appropriate personal protective equipment such as protective gloves and goggles when operating.
In addition, 1-Boc-3-(bromomethyl)azetidine should be stored in a sealed container, away from fire and oxidizing agents. During storage and handling, ensure good ventilation and follow appropriate safety procedures.
Last Update：2024-04-09 21:01:54
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CAS: 253176-93-1
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CAS: 253176-93-1
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