3-Fluoro-3'-hydroxy-[1,1'-biphenyl]-4-carboxylic acid - Names and Identifiers
3-Fluoro-3'-hydroxy-[1,1'-biphenyl]-4-carboxylic acid - Physico-chemical Properties
Molecular Formula | C13H9FO3
|
Molar Mass | 232.21 |
Storage Condition | 2-8°C |
Sensitive | IRRITANT |
MDL | MFCD18312930 |
3-Fluoro-3'-hydroxy-[1,1'-biphenyl]-4-carboxylic acid - Introduction
3-Fluoro-3 '-hydroxy-[1,1'-biphenyl]-4-carboxylic acid (3-fluoro-3 '-hydroxy-[1,1'-biphenyl]-4-carboxylic acid) is an organic compound whose chemical structure contains one hydroxyl and one carboxyl functional group, as well as one fluorine atom and two biphenyl rings. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless crystalline solid
-Molecular formula: C13H9FO3
-Molecular weight: 232.21g/mol
-Melting point: 166-170°C
-Solubility: Soluble in common organic solvents such as methanol, ethanol and dimethyl sulfoxide
Use:
- 3-Fluoro-3 '-hydroxy-[1,1'-biphenyl]-4-carboxylic acid is an active organic intermediate that can be used to synthesize a variety of biologically active compounds.
-It is commonly used in synthetic reactions in the fields of pharmaceutical chemistry, pesticide chemistry and material chemistry.
Preparation Method:
3-Fluoro-3 '-hydroxy-[1,1'-biphenyl]-4-carboxylic acid can be prepared in a variety of ways, one of which is commonly used as follows:
1. First, add cuprous fluoride and an appropriate amount of boric acid in the reaction bottle.
2. 2-Fluorobiphenol and an organic solvent (such as tetrahydrofuran) are added to the reaction flask and the reaction mixture is stirred.
3. Heat the reaction flask to the appropriate reaction temperature and keep the reaction for a period of time.
4. Then, the reaction is stopped and the product is isolated and purified, usually using appropriate solvent extraction, crystallization or column chromatography.
Safety Information:
-When handling 3-Fluoro-3 '-hydroxy-[1,1'-biphenyl]-4-carboxylic acid, follow appropriate laboratory safety practices, such as wearing personal protective equipment such as protective glasses, protective gloves, and protective lab clothes.
-Due to the lack of specific toxicological data, the evaluation of its toxicity and harmfulness is limited. Therefore, use and handle with care and avoid inhalation, ingestion or contact with skin.
-In case of accidental contact with eyes, skin or taking, rinse immediately with plenty of water and seek medical attention as soon as possible.
Last Update:2024-04-09 21:01:54