3-Toluenesulfonyl chloride
m-Toluenesulphonyl chloride
CAS: 1899-93-0
Molecular Formula: C7H7ClO2S
3-Toluenesulfonyl chloride - Names and Identifiers
| Name | m-Toluenesulphonyl chloride |
| Synonyms | m-Tolylsulfonyl chloride m-Toluensulfonyl chloride 3-Toluenesulfonyl chloride M-toluenesulfonyl chloride 3-(Chlorosulphonyl)toluene Toluene-3-sulfonyl chloride m-Toluenesulphonyl chloride 3-methylbenzenesulfonyl chloride 3-Methylbenzene-1-sulfonyl chloride |
| CAS | 1899-93-0 |
| EINECS | 628-747-3 |
| InChI | InChI=1/C7H7ClO2S/c1-6-3-2-4-7(5-6)11(8,9)10/h2-5H,1H3 |
3-Toluenesulfonyl chloride - Physico-chemical Properties
| Molecular Formula | C7H7ClO2S |
| Molar Mass | 190.65 |
| Density | 1.314 g/mL at 25 °C (lit.) |
| Melting Point | 108 °C |
| Boling Point | 252-253 °C (lit.) |
| Flash Point | 225°F |
| Water Solubility | Reacts with water. |
| Vapor Presure | 0.00729mmHg at 25°C |
| BRN | 2087865 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.5490(lit.) |
3-Toluenesulfonyl chloride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns R29 - Contact with water liberates toxic gas |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29049090 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
3-Toluenesulfonyl chloride - Introduction
m-Toluenesulphonyl chloride (English name p-Toluenesulfonyl chloride) is an organic compound. It is represented by the chemical formula C7H7ClO2S, which is formed by the reaction of toluene sulfonic acid and thionyl chloride.
m-Toluenesulphonyl chloride is a colorless or yellowish liquid with a pungent odor. It is soluble in organic solvents such as ethanol, diethyl ether and dichloromethane, but insoluble in water.
m-Toluenesulphonyl chloride is often used as sulfonylation reagent and chlorination reagent in organic synthesis. It can convert hydroxyl groups (-OH) into sulfonyloxy groups (-SO2Cl), thereby introducing more active groups, which are used in the synthesis of organic compounds such as drugs, dyes and pesticides. In addition, it can also be used to synthesize aromatic aldehydes, aromatic amines and Aromatic ketones.
When preparing m-Toluenesulphonyl chloride, the product can be obtained by reacting toluene sulfonic acid with thionyl chloride under appropriate conditions, usually heating and stirring at room temperature for several hours, and then cooling, crystallization and filtration.
m-Toluenesulphonyl chloride is irritating and corrosive, care should be taken to avoid contact with skin and eyes. Personal protective equipment such as protective gloves, goggles and protective clothing should be worn during use or operation. In addition, keep away from fire and oxidant when stored, and avoid contact with combustibles and combustible gases. If inhaled or ingested by mistake, seek medical attention immediately.
m-Toluenesulphonyl chloride is a colorless or yellowish liquid with a pungent odor. It is soluble in organic solvents such as ethanol, diethyl ether and dichloromethane, but insoluble in water.
m-Toluenesulphonyl chloride is often used as sulfonylation reagent and chlorination reagent in organic synthesis. It can convert hydroxyl groups (-OH) into sulfonyloxy groups (-SO2Cl), thereby introducing more active groups, which are used in the synthesis of organic compounds such as drugs, dyes and pesticides. In addition, it can also be used to synthesize aromatic aldehydes, aromatic amines and Aromatic ketones.
When preparing m-Toluenesulphonyl chloride, the product can be obtained by reacting toluene sulfonic acid with thionyl chloride under appropriate conditions, usually heating and stirring at room temperature for several hours, and then cooling, crystallization and filtration.
m-Toluenesulphonyl chloride is irritating and corrosive, care should be taken to avoid contact with skin and eyes. Personal protective equipment such as protective gloves, goggles and protective clothing should be worn during use or operation. In addition, keep away from fire and oxidant when stored, and avoid contact with combustibles and combustible gases. If inhaled or ingested by mistake, seek medical attention immediately.
Last Update：2024-04-09 20:52:54
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