3-chloro-5-(trifluoromethyl) pyridin-2-ol

3-chloro-5-(trifluoromethyl) pyridin-2-ol - Names and Identifiers

Name	3-chloro-5-(trifluoromethyl) pyridin-2-ol
Synonyms	3-chloro-5-(trifluoromethyl)pyridin-2-ol 3-chloro-5-(trifluoromethyl) pyridin-2-ol 3-chloro-5-(trifluoromethyl)pyridine-2-ol 3-Chloro-5-(trifluoromethyl)-2(1H)-pyridinone 3-chloro-5-(trifluoromethyl)pyridin-2(1H)-one 3-Chloro-5-(trifluoromethyl)-2(3H)-pyridinone 2-Hydroxy-3-chloro-5-(trifluoromethyl)pyridine 2(3H)-PYRIDINONE, 3-CHLORO-5-(TRIFLUOROMETHYL)- 3-chloro-5-(trifluoroMethyl)-2,3-dihydropyridin-2-one
CAS	79623-37-3
InChI	InChI=1/C6H3ClF3NO/c7-4-1-3(6(8,9)10)2-11-5(4)12/h1-2,4H

3-chloro-5-(trifluoromethyl) pyridin-2-ol - Physico-chemical Properties

Molecular Formula	C6H3ClF3NO
Molar Mass	197.5423296
Density	1.56
Boling Point	175℃
Flash Point	60℃
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.488

3-chloro-5-(trifluoromethyl) pyridin-2-ol - Introduction

3-choro-5-(trifluoromethyl) pyridin-2-ol (3-choro-5-(trifluoromethyl) pyridin-2-ol) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless to light yellow crystal or powder
-Molecular formula: C6H3ClF3NO
-Molecular weight: 195.54g/mol
-melting point: 52-56 ℃
-Boiling point: 206-210 ℃
-Solubility: Slightly soluble in water, soluble in ethanol and ether solvents.

Use:
3-chloro-5-(trifluoromethyl) pyridin-2-ol is a commonly used reagent in organic synthesis, which is widely used in the fields of drug synthesis, pesticide synthesis and material chemistry. As a fluoro-substituted reagent, it can participate in alkylation reaction, chlorination reaction and so on.

Preparation Method:
3-chloro-5-(trifluoromethyl) pyridin-2-ol can be prepared by the following reaction:
1. Under alkaline conditions, 2-hydroxy-3-chloropyridine reacts with trifluoromethyl ketone to generate 3-chloro-5-(trifluoromethyl) pyridin-2-ol.
2. The reaction process needs to pay attention to temperature and pH control.

Safety Information:
-3-choro-5-(trifluoromethyl) pyridin-2-ol has low toxicity, but it still needs to be handled with caution when used in experiments or industrial production.
-During the manipulation, try to avoid contact with skin and eyes, and ensure good ventilation conditions.
-In case of contact or inhalation, rinse immediately with plenty of water and seek medical attention immediately.
-Waste shall be disposed of in accordance with relevant regulations and shall not be released into the environment.

Please note that when using chemical reagents, follow proper laboratory procedures and refer to the relevant safety data sheet (SDS) of the chemical for comprehensive safety information.

Last Update：2024-04-09 19:05:52