| Name | Soy bean phospholipid |
| Synonyms | DDLZ fabaceous lecithin Soy bean phospholipid 3-sn-phosphatidyl choline from soybean |
| Storage Condition | 2-8°C |
| Use | Uses for chemical industry, light industry industry |
action
soybean phospholipid is the general term for lecithin, cephalin and muscle phospholipid contained in soybean. All cells in the human body contain lecithin, which is the main component of the cell membrane and plays an important role in maintaining the normal structure and function of cells and promoting cell growth and development.
chemical properties
P> Phospholipid is a major compound fat in nature. It is widely found in the brain, nervous system, heart, liver and other organs of human and animal bodies, as well as various microorganisms, eggs and most plant seeds. Almost all biological cells contain phospholipids. Industrial grade soybean phospholipids are divided into three categories according to color, bleached and twice bleached, which are brown to light yellow respectively. The purified lecithin is nearly white, and gradually turns yellow to brown after being placed, without odor. Mp160 ℃. Soluble in vegetable oil and ether, soluble in ethanol, insoluble in acetone. Very hygroscopic. It can form insoluble complexes with cadmium salts. At any pH value, it exists in a zwitterionic state, so it has surface activity.use
Excipient, used for emulsification of oral preparations. It can be used to treat hyperlipidemia, acute cerebral infarction, and neurasthenia. Soy phospholipid is used for intravenous injection. Only a few patients have brief temperature rise, chills, headache, chest tightness, nausea, arthralgia and other reactions after infusion, which can subside by themselves without treatment. Hyperlipidemia, liver and kidney damage should be used with caution.
production method
method 1. using crude phospholipids as raw materials to prepare soybean phospholipids for injection
preparation of extract take crude phospholipid, add 1.5 times the amount of industrial acetone, fully stir, stand, pour out the upper liquid to recover acetone, add acetone to the precipitate, fully stir, stand, repeatedly treat the precipitate for 4-5 times, until the lotion is checked with filter paper for no oil trace, and the precipitate is combined. Vacuum suction filtration to dryness to obtain granular phospholipids. Add 95% medicinal ethanol, heat and reflux for 1h, cool, extract the extract, extract the precipitate with ethanol for 2 times, combine the extract, put it into a cold storage at -5 ℃ for the night, and take it out the next day.
crude phospholipid [acetone] & rarr; granular phospholipid [ethanol] & rarr; extract
preparation of filtrate heating the extracted liquid, adding alumina, heating reflux for 1h, cooling, releasing alumina and extract, adding activated carbon for injection, heating reflux stirring for 1h, removing pyrogen, filtering to obtain filtrate.
Extract [Al2O3]& rarr; Upper layer [activated carbon] & rarr; filtrate
preparation of soybean phospholipids for injection: vacuum concentrate the filtrate to obtain a concentrated solution, add activated carbon, heat, reflux and stir for 1h, filter, filter the filtrate in a constant temperature water bath, vacuum and vacuum distillation to dry, add acetone and wash for 5 to 6 times to obtain soybean phospholipids for injection.
filtrate [concentration] & rarr; Concentrate [activated carbon] & rarr;[acetone] bean phospholipid for injection
method 2. using powdered soybean lecithin as raw material to prepare soybean phospholipid for injection
take powdered soybean lecithin, dissolve it in water, add sodium sulfate to salt out, precipitate phospholipids, dry under reduced pressure, reflux the extract with 95% ethanol to obtain lecithin ethanol solution. Add active aluminum, stir and adsorb impurities, and filter to obtain mother liquor after removing adsorbed impurities. Add activated carbon to stir, decolorize, filter, and distill under reduced pressure to dry to obtain a viscous paste. Add anhydrous acetone to dehydrate and deoil to obtain viscous refined soybean phospholipids for injection.
powdered soybean phospholipid [water] & rarr;[Na2SO4] phospholipid [95% ethanol] & rarr; Soy phospholipid ethanol thick solution [Al2O3]& rarr; Mother liquor [activated carbon] & rarr;[acetone] soybean phospholipid for injection
method 3. using soybean oil as raw material
preparation of crude phospholipids soybean oil is added with 2%-3% water, mixed at 50-70 ℃, or water vapor is introduced into soybean oil to obtain phospholipid hydrate, which is pumped into a centrifugal separator for separation and mud is collected to obtain crude phospholipids.
soybean oil [2%-3% water] & rarr;[50-70 ℃] phospholipid hydrate [separation] & rarr; Crude phospholipid
dry crude phospholipid dehydrated and dried until the water content is less than 1%, which can eventually be reduced to 0.5%. After drying, quickly cool to below 50°C to prepare a finished soybean phospholipid product, which is packaged immediately to prevent moisture absorption. There are two drying forms, namely intermittent drying and continuous drying. Intermittent drying refers to vacuum drying at 65-70 ℃. Continuous drying refers to rapid vacuum drying at about 115 ℃ with a film evaporator.
crude phospholipids [dried] & rarr; finished soybean phospholipids