30827-99-7
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
CAS: 30827-99-7
Molecular Formula: C8H11ClFNO2S
30827-99-7 - Names and Identifiers
| Name | 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride |
| Synonyms | AEBSF AEBSF HCI AEBSF HCL 2,4,6-tribromo-3,5-difluoropyridine BROMOPHENOL BLUE NA SALT PROTEOMICS GR 2-[4-(Fluorosulfonyl)phenyl]ethanaminium chloride 4-(2-AMinoethyl)benzenesulfonyl fluoride hydrochlorid 4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride 2-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride 4-(Fluorosulphonyl)phenethylamine hydrochloride, 2-[4-(Fluorosulphonyl)phenyl]ethylamine hydrochloride, AEBSF |
| CAS | 30827-99-7 |
| EINECS | 608-547-2 |
| InChI | InChI=1/C8H10FNO2S.ClH/c9-13(11,12)8-4-2-1-3-7(8)5-6-10;/h1-4H,5-6,10H2;1H |
| InChIKey | WRDABNWSWOHGMS-UHFFFAOYSA-N |
30827-99-7 - Physico-chemical Properties
| Molecular Formula | C8H11ClFNO2S | |
| Molar Mass | 239.69 | |
| Melting Point | 175-177 °C | |
| Boling Point | 337°C at 760 mmHg | |
| Flash Point | 157.6°C | |
| Water Solubility | 10 g/L (20 ºC) | |
| Solubility | Soluble in water | |
| Vapor Presure | 7.72E-05mmHg at 25°C | |
| Appearance | White powder | |
| Color | White | |
| BRN | 7604627 | |
| PH | pH3.0～5.0 (10g/L, 25℃) | |
| Storage Condition | 2-8°C | |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator | |
| Sensitive | Moisture Sensitive | |
| MDL | MFCD00132962 | |
| Physical and Chemical Properties |
| |
| Use | Purpose: protease inhibitor | |
| In vitro study | AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. | |
| In vivo study | AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection.AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. |
30827-99-7 - Risk and Safety
| Risk Codes | R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3261 |
| WGK Germany | 3 |
| HS Code | 29214990 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
30827-99-7 - Introduction
Irreversible serine protease inhibitor. The inhibition constants were similar to those of PMSF and DFP. AEBSF can inhibit trypsin, chymotrypsin, plasmin, kallikrein and thrombin. As a substitute for PMSF and DFP, AEBSF has lower toxicity, better water solubility and better stability in aqueous solution. AEBSF has been used in cell culture at concentrations of up to 0.25mM.
Last Update：2022-10-16 17:24:29
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Spot supply
Product Name: AEBSF hydrochloride Visit Supplier Webpage Request for quotationCAS: 30827-99-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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