4',6,7-trihydroxyisoflavone
4',6,7-trihydroxyisoflavone
CAS: 17817-31-1
Molecular Formula: C15H10O5
4',6,7-trihydroxyisoflavone - Names and Identifiers
| Name | 4',6,7-trihydroxyisoflavone |
| Synonyms | DEMETHYLTEXASIN 6,7,4'-TRIHYDROXYISOFLAVONE 4',6,7-trihydroxyisoflavone 4',6,7-TRIHYDROXYISOFLAVONE TRIHYDROXYISOFLAVONE, 4',6,7- TRIHYDROXYISOFLAVONE, 4',6,7-(RG) 6,7-Dihydroxy-3-(4-hydroxyphenyl) DESMETHYLGLYCITEIN (4',6,7-TRIHYDROXYISOFLAVONE) 6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one |
| CAS | 17817-31-1 |
| InChI | InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-14-6-13(18)12(17)5-10(14)15(11)19/h1-7,16-18H |
4',6,7-trihydroxyisoflavone - Physico-chemical Properties
| Molecular Formula | C15H10O5 |
| Molar Mass | 270.24 |
| Density | 1.548±0.06 g/cm3(Predicted) |
| Melting Point | >280℃ |
| Boling Point | 587.1±50.0 °C(Predicted) |
| Flash Point | 229.7°C |
| Solubility | soluble in Dimethylformamide |
| Vapor Presure | 2.21E-14mmHg at 25°C |
| Appearance | Solid |
| Color | Light yellow to Brown to Dark green |
| pKa | 6.85±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.732 |
| MDL | MFCD00016953 |
4',6,7-trihydroxyisoflavone - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
4',6,7-trihydroxyisoflavone - Reference Information
| Plant source: | Fructus Aurantii Immaturus |
| biological activity | Desmethylglycitein (4 ',6,7-Trihydroxyisoflavone), a metabolite of daidzein, derived from soybean Glycine max, has antioxidant and anticancer activity. Desmethylglycitein directly binds CDK1 and CDK2 in vivo and inhibits CDK1 and CDK2 activities. Desmethylglycitein, a direct inhibitor of protein kinase C (PKC)α, inhibits solar ultraviolet (sUV)-induced matrix metalloproteinase 1 (MMP1) in normal human skin fibroblasts. Desmethylglycitein binds to PI3K in cytoplasm in a ATP competitive manner, inhibiting the activity of PI3K and downstream signaling cascades, thereby inhibiting fat formation in 3T3-L1 preadipocytes. |
| Cell Line: | HCT-116 cells HCT-116 and DLD1 cells HCT-116 cells |
| Concentration: | 0, 12.5, 25, 50 or 100 μM 0, 25, 50 or 100 μM 0, 25, 50 or 100 μM |
| Incubation Time: | 24, 48 or 72 hours 48 hours 24, 48 or 72 hours |
| Result: | Inhibited anchorage-dependent and -independent growth of HCT-116 cells. Inhibited CDK1,CDK2 expression. Induces cell cycle arrest of HCT-116 cells at S and G2/M phases. Decreased tumor growth, volume and weight of HCT-116 xenografts. |
| Animal Model: | Female athymic nude mice subcutaneously injected with HCT-116 cells |
| Dosage: | 5 or 25 mg/kg |
| Administration: | Intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days |
Last Update：2024-04-09 20:45:29
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