4'-Trifluoromethylbiphenyl-4-carbaldehyde

4'-Trifluoromethylbiphenyl-4-carbaldehyde - Names and Identifiers

Name	4'-Trifluoromethylbiphenyl-4-carbaldehyde
Synonyms	AKOS BAR-0197 4-[4-(trifluoromethyl)phenyl]benzaldehyde 4'-Trifluoromethylbiphenyl-4-carbaldehyde 4-[4-(TRIFLUOROMETHYL)PHENYL]BENZALDEHYDE 4'-Trifluoromethyl-biphenyl-4-carbaldehyde 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE 4'-(Trifluoromethyl)-Biphenyl-4-Carboxaldehyde 4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBALDEHYDE 4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXALDEHYDE 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde [1,1'-Biphenyl]-4-carboxaldehyde,4'-(trifluoroMethyl)-
CAS	90035-34-0
EINECS	618-368-1
InChI	InChI=1/C14H9F3O/c15-14(16,17)13-7-5-12(6-8-13)11-3-1-10(9-18)2-4-11/h1-9H

4'-Trifluoromethylbiphenyl-4-carbaldehyde - Physico-chemical Properties

Molecular Formula	C14H9F3O
Molar Mass	250.22
Density	1.251±0.06 g/cm3(Predicted)
Melting Point	70-72°C
Boling Point	319.7±42.0 °C(Predicted)
Flash Point	156.624°C
Vapor Presure	0mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.539
Use	This product is for scientific research only and shall not be used for other purposes.

4'-Trifluoromethylbiphenyl-4-carbaldehyde - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

4'-Trifluoromethylbiphenyl-4-carbaldehyde - Reference Information

introduction

4 '-trifluoromethyldiphenyl -4-formaldehyde can be used as an intermediate in pharmaceutical synthesis, can be prepared by the reaction of bromobenzaldehyde and p-trifluoromethylphenylboronic acid, and can be used to prepare compound 1-(4'-(trifluoromethyl)-[1,1 '-biphenyl]-4-yl) butyl-1-ol.

preparation

4.625g(25mmol) p-bromobenzaldehyde, 9.495g(50mmol) p-trifluoromethylphenylboronic acid, 1.445g(1.25mmol) tetrakis (triphenylphosphine) palladium, 13.8g(100mmol) potassium carbonate, 100mL ethylene glycol dimethyl ether and 15mL water are mixed, nitrogen is pumped and exhausted for three times, and the reaction is 110 degrees for 24 hours. After the reaction, dichloromethane was used for extraction, the organic phase was washed with water and saturated salt water, anhydrous magnesium sulfate was dried, and the product (3.878g) was separated by column chromatography with a yield of about 62%.

Last Update：2024-04-09 21:54:55