4,4,5,5-tetramethyl-2-naphthalen-2-yl-1,3,2-dioxaborolane
Naphthalene-2-boronic acid pinacol ester
CAS: 256652-04-7
Molecular Formula: C16H19BO2
4,4,5,5-tetramethyl-2-naphthalen-2-yl-1,3,2-dioxaborolane - Names and Identifiers
4,4,5,5-tetramethyl-2-naphthalen-2-yl-1,3,2-dioxaborolane - Physico-chemical Properties
| Molecular Formula | C16H19BO2 |
| Molar Mass | 254.13 |
| Density | 1.06±0.1 g/cm3(Predicted) |
| Melting Point | 64.0 to 68.0 °C |
| Boling Point | 378.7±11.0 °C(Predicted) |
| Flash Point | 182.82°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.558 |
4,4,5,5-tetramethyl-2-naphthalen-2-yl-1,3,2-dioxaborolane - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| HS Code | 29319090 |
4,4,5,5-tetramethyl-2-naphthalen-2-yl-1,3,2-dioxaborolane - Introduction
Naphthalene-2-boronic acid pinacol ester, also known as 2-napthaleneboronic acid pinacol ester, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless crystalline or powdery solid
-Molecular formula: C18H21BO2
-Molecular weight: 274.17g/mol
-Melting point: 90-91 ° C
-Boiling point: 401.1 ° C
-Solubility: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane
Use:
- Naphthalene-2-boronic acid pinacol ester is a compound commonly used in organic synthesis. It is mainly used in organometallic catalytic reactions and Suzuki-Miyaura coupling reactions, and is used as an important borate reagent
-It can be used as a lively nucleophile to participate in various reactions, such as root-specific reaction, nucleophilic substitution reaction, etc.
-can be used to synthesize pesticides, complexes and other pharmaceutical intermediates
-In drug research, Naphthalene-2-boronic acid pinacol ester is also used as a starting material for kinase inhibitors and compound screening
Method:
Naphthalene-2-boronic acid pinacol ester can be prepared by the two-step reaction of caustic soda and boric acid. The specific steps are as follows:
1. The naphthalene boronic acid and pinacol ester are mixed and heated under solvent-free conditions.
2. Add an appropriate amount of caustic soda, and maintain the temperature of the reaction mixture at 100-110 ° C. Under an inert atmosphere, and react for 12-24 hours.
3. The reaction mixture was cooled to room temperature and neutralized with water and acid.
4. Through extraction, distillation and crystallization operations, purification to obtain the Naphthalene-2-boronic acid pinacol ester product.
Safety Information:
- Naphthalene-2-boronic acid pinacol ester is of low toxicity, as an organic compound, it should follow appropriate laboratory safety procedures and avoid inhalation, intake or skin contact
-During operation, avoid contact with strong oxidants, acidic substances and high temperatures to prevent danger
-Wear appropriate protective equipment, such as gloves, goggles and protective clothing, to ensure good ventilation
-In case of contact with skin or eyes, rinse with plenty of water and seek medical help
Nature:
-Appearance: Colorless crystalline or powdery solid
-Molecular formula: C18H21BO2
-Molecular weight: 274.17g/mol
-Melting point: 90-91 ° C
-Boiling point: 401.1 ° C
-Solubility: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane
Use:
- Naphthalene-2-boronic acid pinacol ester is a compound commonly used in organic synthesis. It is mainly used in organometallic catalytic reactions and Suzuki-Miyaura coupling reactions, and is used as an important borate reagent
-It can be used as a lively nucleophile to participate in various reactions, such as root-specific reaction, nucleophilic substitution reaction, etc.
-can be used to synthesize pesticides, complexes and other pharmaceutical intermediates
-In drug research, Naphthalene-2-boronic acid pinacol ester is also used as a starting material for kinase inhibitors and compound screening
Method:
Naphthalene-2-boronic acid pinacol ester can be prepared by the two-step reaction of caustic soda and boric acid. The specific steps are as follows:
1. The naphthalene boronic acid and pinacol ester are mixed and heated under solvent-free conditions.
2. Add an appropriate amount of caustic soda, and maintain the temperature of the reaction mixture at 100-110 ° C. Under an inert atmosphere, and react for 12-24 hours.
3. The reaction mixture was cooled to room temperature and neutralized with water and acid.
4. Through extraction, distillation and crystallization operations, purification to obtain the Naphthalene-2-boronic acid pinacol ester product.
Safety Information:
- Naphthalene-2-boronic acid pinacol ester is of low toxicity, as an organic compound, it should follow appropriate laboratory safety procedures and avoid inhalation, intake or skin contact
-During operation, avoid contact with strong oxidants, acidic substances and high temperatures to prevent danger
-Wear appropriate protective equipment, such as gloves, goggles and protective clothing, to ensure good ventilation
-In case of contact with skin or eyes, rinse with plenty of water and seek medical help
Last Update：2024-04-09 15:17:56
Supplier List
Spot supply
Product Name: Naphthalene-2-boronic acid pinacol ester Visit Supplier Webpage Request for quotationCAS: 256652-04-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Naphthalene-2-boronic acid pinacol ester Visit Supplier Webpage Request for quotationCAS: 256652-04-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History