Molecular Formula | C15H23BN2O3 |
Molar Mass | 290.17 |
Density | 1.13±0.1 g/cm3(Predicted) |
Melting Point | 135-139 °C (lit.) |
Boling Point | 440.9±45.0 °C(Predicted) |
Flash Point | 220.5°C |
Vapor Presure | 5.67E-08mmHg at 25°C |
pKa | 5.58±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.53 |
MDL | MFCD04039874 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S43A - S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | 2811 |
WGK Germany | 3 |
Hazard Class | IRRITANT |
Use | 6-(morpholin-4-yl) pyridine-3-borate pinacol ester, Chinese alias: 6-(4-morpholinyl) pyridine-3-borate pinacol ester, is an important pharmaceutical and chemical intermediate. |
Preparation | Using 2,5-dibromopyridine and morpholine as starting materials, 6-(morpholine-4-yl) pyridine -3-borate pinacol ester [1] was prepared after substitution and boric acid esterification reaction. The synthesis reaction formula is as follows: Fig. 1 Preparation of the synthesis reaction formula N-(5-bromopyridine -2-yl) morpholine of 6-(morpholine -4-yl) pyridine -3-borate pinacol ester 150 mL dichloromethane is added into a 500 mL three-mouth bottle, and 30g(125. 37 mmol) morpholine and 19. 1g(188. 06 mmol) triethylamine are added in sequence at 0 ℃, slowly add 15. 6g(137. 91 mmol) 2,5-dibromopyridine, drop it, react at room temperature for 4 h, and finish the reaction. The reaction liquid is poured into water, dichloromethane is extracted, dried, concentrated under reduced pressure, dissolved residue with appropriate amount of ether, crystallized, filtered by suction, and washed with ether to obtain white solid N-(5-bromopyridine-2-yl) Morpholine. Preparation of 6-(morpholine-4-yl) pyridine -3-borate pinacol ester 150 mL 1,4-dioxane in a single-mouth bottle of 500 mL, 30g(157. 89 mmol)2-fluoro -5 bromoaniline, 42. 2g(166. 14mmol) pinacol biborate, 46. 5g(473. 67 mmol) potassium acetate, 2. 6g(3. 16 mmol)([1,1 '-bis (diphenylphosphine) ferrocene] palladium dichloride were added in sequence under N 2 protection, heat to 90 ℃ for reflux reaction for 5 h, after reflux, cool to room temperature, pour the reaction liquid into water, extract ethyl acetate, add 10 g of activated carbon to the obtained organic phase, stir for 10 min, filter, dry, and concentrate under reduced pressure to obtain white solid 6-(morpholine -4-yl) pyridine -3-borate pinacol ester. |