4-氨基-5-氯-2-甲氧基苯甲酸

4-氨基-5-氯-2-甲氧基苯甲酸 - Names and Identifiers

Name	4-Amino-5-chloro-2-methoxybenzoic acid
Synonyms	EU-0018508 EINECS 230-582-3 4-amino-5-chloro-2-methoxybenzoate 5-Chloro-4-aMino-2-ethoxybenzoic acid 4-Amino-5-chloro-2-methoxybenzoic acid 5-Chloro-4-aMino-2-Methoxybenzoic Acid Benzoic acid, 4-aMino-5-chloro-2-Methoxy-
CAS	7206-70-4
EINECS	230-582-3
InChI	InChI=1/C8H8ClNO3/c1-13-7-3-6(10)5(9)2-4(7)8(11)12/h2-3H,10H2,1H3,(H,11,12)/p-1

4-氨基-5-氯-2-甲氧基苯甲酸 - Physico-chemical Properties

Molecular Formula	C8H8ClNO3
Molar Mass	201.61
Density	1.3639 (rough estimate)
Melting Point	206 °C (dec.) (lit.)
Boling Point	369.7±42.0 °C(Predicted)
Flash Point	177.4°C
Solubility	Soluble in water
Vapor Presure	4.06E-06mmHg at 25°C
Appearance	White to slightly beige powder
Color	White to slightly beige
pKa	4.38±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Sensitive	Sensitive to air
Refractive Index	1.5800 (estimate)
MDL	MFCD00038794

4-氨基-5-氯-2-甲氧基苯甲酸 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29225090

4-氨基-5-氯-2-甲氧基苯甲酸 - Introduction

Acid is an organic compound. The following are some properties, uses, preparation and safety information about the compound:

Nature:
-Appearance: White crystalline solid
-Molecular formula: C8H8ClNO3
-Molecular weight: 209.61g/mol
-Melting Point: 214-217°C
-Solubility: Slightly soluble in water, easily soluble in organic solvents such as alcohols and ketones

Use:
The compound is mainly used in the field of medicine, as an intermediate for the synthesis of other drugs. It can be used as a raw material for drugs, especially for the synthesis of some non-steroidal anti-inflammatory drugs and hormone drugs.

Preparation Method:
The acid can be obtained by the following synthetic route:
1. starting from p-methoxybenzoic acid, it reacts to generate p-methoxyphenyl carboxylic acid.
2. p-methoxyphenyl carboxylic acid reacts with phosphorus pentachloride to generate 4-chloro-2-methoxybenzoic acid after electrophilic substitution reaction.
3. 4-Chloro-2-methoxybenzoic acid reacts with ammonia to obtain 4-amino-2-methoxybenzoic acid.
4. Finally, 4-amino -2-methoxybenzoic acid was chlorinated to obtain acid.

Safety Information:
-The compound may be irritating to the eyes, skin and respiratory system and direct contact should be avoided.
-In handling and storage, appropriate safety measures must be taken, such as wearing chemical protective glasses and gloves.
-When handling, make sure to work under well-ventilated laboratory conditions.
-When storing, it should be stored in a dry, cool place, away from fire and oxidizing agents.
-In the use or disposal process, should comply with the relevant safety procedures and environmental regulations.

Last Update：2024-04-09 21:00:56