4-硝基-2-三氟甲基苯甲酸

Name	4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID
Synonyms	RARECHEM AL BO 1444 4-NITRO-2-(TRIFLUOROMETHYL)BENZOIC ACID 4-Nitro-2-(trifluoromethyl)benzoyl chloride Benzoyl chloride, 4-nitro-2-(trifluoromethyl)-
CAS	98187-15-6

Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
Hazard Note	Irritant

introduction	4-nitro -2-(trifluoromethyl) benzoic acid is white to light yellow crystal powder, density: 1.596g/cm3, boiling point: 321.4 c at 760mmHg, melting point: 138-142 c (lit.). It is an important pharmaceutical and pesticide intermediate, which can be prepared by a variety of synthetic routes.
use	4-nitro-2-(trifluoromethyl) benzoic acid is a white to light yellow crystal powder, which is mainly used as an important pharmaceutical and pesticide intermediate.
preparation	add 5g of 2-trifluoromethylbenzocyanine to the three-mouth bottle, add 10 mL of nitrating agent dropwise, raise the temperature to 70°C, stir magnetically for 3 h, and end the reaction. Add 30 ml of water, separate the liquid, take the organic layer, the water layer is extracted once with 30 ml of ethyl acetate, combine the organic phase, dry with anhydrous sodium sulfate, and spin steaming to obtain 6.5 g solid, 4-nitro-2-(trifluoromethyl) benzoic acid.

Last Update：2024-04-09 15:17:30