4-羧丁基三苯基溴化膦

Name	(4-Carboxybutyl)triphenylphosphonium bromide
Synonyms	NSC 147756 (4-Carboxybut (4-Carboxybutyl)triphenylphosp (4-carboxybutyl)(triphenyl)phosphonium 4-carboxybutyltripheyl phosphonium bromide (4-CARBOXYBUTYL)TRIPHENYLPHOSPHONIUM BROMIDE (4-Carboxybutyl)triphenylphosphonium bromide 4-carboxybutyl(triphenyl)phosphanium,bromide 4-carboxybutyl triphenyl phosphonium bromide (4-Carboxybutyl) triphenylphosphonium brimide (4-Carboxybutyl)triphenyl-phosphonium bromide (4-Carboxy-butyl)-triphenyl-phosphonium bromide Phosphonium, (4-carboxybutyl)triphenyl-, bromide (4-(4-carboxybutyl)phenyl)diphenylphosphonium bromide phosphonium, (4-carboxybutyl)triphenyl-, hydrobromide
CAS	17814-85-6
EINECS	241-782-5
InChI	InChI=1/C23H23O2P.BrH/c24-23(25)18-10-11-19-26(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22;/h1-9,12-17H,10-11,18-19H2;1H/p+1
InChIKey	KQJPHSBFOSLICV-UHFFFAOYSA-N

Molecular Formula	C23H24BrO2P
Molar Mass	443.31
Density	1.371 at 20℃
Melting Point	204-207°C(lit.)
Boling Point	324.7-327.4℃ at 101.93-102.15kPa
Flash Point	195°(383°F)
Water Solubility	Soluble in ethanol, methanol and soluble water. Insoluble in toluene and hexane.
Solubility	DMSO, Methanol, Water
Vapor Presure	0Pa at 25℃
Appearance	White-like crystal
Color	White to Off-White
BRN	3586477
Storage Condition	Store below +30°C.
Sensitive	Hygroscopic
MDL	MFCD00011906

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	3278
WGK Germany	3
HS Code	29310095

LogP	0.146
background	prostaglandin drugs are a large class of drugs developed by chemical modification on the basis of functional substances found in human prostaglandins. They belong to biomimetic synthetic compounds and are widely used in the treatment of cardiovascular, gynecological, digestive system, ophthalmology and other diseases. The side chain 4-carboxybutyltriphenylphosphine bromide is required in all known prost drug synthesis. The acquisition of this side chain is essential for the synthesis of prost drugs.
application	4-carboxybutyltriphenylphosphine bromide is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in laboratory organic synthesis and pharmaceutical research and development In the process, it is mainly used as an intermediate of the bulk drug bimatoprost.
Synthesis method	5-bromo-1-pentanol is reacted with hypochlorite in a solvent, TEMPO and a phase transfer catalyst, and then 5-bromovaleric acid is collected from the reaction product. 5-bromovaleric acid is reacted with triphenylphosphine in a solvent, and then from the reaction liquid, the target product 4-carboxybutyltriphenylphosphine bromide was collected.
use	bimatoprost intermediate

Last Update：2024-04-10 22:29:15

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