4-(1H-Pyrazol-4-yl)benzoic acid
4-(1H-Pyrazol-4-yl)benzoic acid
CAS: 1017794-47-6
Molecular Formula: C10H8N2O2
4-(1H-Pyrazol-4-yl)benzoic acid - Names and Identifiers
| Name | 4-(1H-Pyrazol-4-yl)benzoic acid |
| Synonyms | AKOS BAR-1968 4-(4-Pyrazolyl)benzoic Acid 4-(1H-Pyrazol-4-yl)benzoic acid 4-(1H-PYRAZOL-4-YL)BENZOIC ACID Benzoic acid, 4-(1H-pyrazol-4-yl)- |
| CAS | 1017794-47-6 |
4-(1H-Pyrazol-4-yl)benzoic acid - Physico-chemical Properties
| Molecular Formula | C10H8N2O2 |
| Molar Mass | 188.19 |
| Density | 1.355±0.06 g/cm3(Predicted) |
| Boling Point | 471.5±38.0 °C(Predicted) |
| pKa | 4.09±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD06803014 |
4-(1H-Pyrazol-4-yl)benzoic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
4-(1H-Pyrazol-4-yl)benzoic acid - Upstream Downstream Industry
4-(1H-Pyrazol-4-yl)benzoic acid - Introduction
4-(1H-Pyrazol-4-yl)benzoic acid is an organic compound with the chemical formula C11H8N2O2.
Nature:
-Appearance: 4-(1H-Pyrazol-4-yl)benzoic acid is a white to pale yellow crystalline powder.
-Melting point: About 210 degrees Celsius.
-Solubility: Soluble in some organic solvents (such as chloroform, dimethylformamide).
Use:
- 4-(1H-Pyrazol-4-yl) benzic acid is often used as an important intermediate in organic synthesis reactions.
-It can be used to synthesize drugs, pesticides and other compounds with biological activity.
-In organic chemistry research and experiments, it is also widely used as a ligand or group.
Method:
There are many preparation methods for 4-(1H-Pyrazol-4-yl)benzoic acid. One common method is the following reaction:
First, take 1-bromo-4-nitrobenzene (1-bromo-4-nitrobenzene) and 1-phenyl-1H-pyrazole-4-amine (4-aminopyrazole) for reaction, generation of 4-bromo-1H-pyrazole (4-bromo-1H-pyrazole);
Then, 4-bromo-1H-pyrazole and benzoic acid are subjected to a palladium-catalyzed coupling reaction to generate 4-(1H-Pyrazol-4-yl)benzoic acid.
Safety Information:
- 4-(1H-Pyrazol-4-yl)benzoic acid is generally considered to be relatively safe under regular conditions of use.
-Take appropriate personal protective measures during handling and handling, such as wearing gloves, respiratory protective equipment, etc.
-It should not be in contact with substances such as strong oxidants and strong acids to avoid possible dangerous reactions.
-For those who are not familiar with the compound before use, it is recommended to read the relevant safety materials and follow the correct experimental practice.
Nature:
-Appearance: 4-(1H-Pyrazol-4-yl)benzoic acid is a white to pale yellow crystalline powder.
-Melting point: About 210 degrees Celsius.
-Solubility: Soluble in some organic solvents (such as chloroform, dimethylformamide).
Use:
- 4-(1H-Pyrazol-4-yl) benzic acid is often used as an important intermediate in organic synthesis reactions.
-It can be used to synthesize drugs, pesticides and other compounds with biological activity.
-In organic chemistry research and experiments, it is also widely used as a ligand or group.
Method:
There are many preparation methods for 4-(1H-Pyrazol-4-yl)benzoic acid. One common method is the following reaction:
First, take 1-bromo-4-nitrobenzene (1-bromo-4-nitrobenzene) and 1-phenyl-1H-pyrazole-4-amine (4-aminopyrazole) for reaction, generation of 4-bromo-1H-pyrazole (4-bromo-1H-pyrazole);
Then, 4-bromo-1H-pyrazole and benzoic acid are subjected to a palladium-catalyzed coupling reaction to generate 4-(1H-Pyrazol-4-yl)benzoic acid.
Safety Information:
- 4-(1H-Pyrazol-4-yl)benzoic acid is generally considered to be relatively safe under regular conditions of use.
-Take appropriate personal protective measures during handling and handling, such as wearing gloves, respiratory protective equipment, etc.
-It should not be in contact with substances such as strong oxidants and strong acids to avoid possible dangerous reactions.
-For those who are not familiar with the compound before use, it is recommended to read the relevant safety materials and follow the correct experimental practice.
Last Update：2024-04-09 21:01:54
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