4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
4-maleimidobutyric acid
CAS: 57078-98-5
Molecular Formula: C8H9NO4
4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid - Names and Identifiers
4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid - Physico-chemical Properties
| Molecular Formula | C8H9NO4 |
| Molar Mass | 183.16 |
| Density | 1.395±0.06 g/cm3(Predicted) |
| Melting Point | 95-98°C |
| Boling Point | 400.1±28.0 °C(Predicted) |
| Flash Point | 195.8°C |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| Vapor Presure | 1.61E-07mmHg at 25°C |
| Appearance | Solid |
| Color | White to Pale Yellow |
| BRN | 1455876 |
| pKa | 4.59±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.553 |
| MDL | MFCD00043139 |
| Use | Gamma-maleimidobutyric acid may be used as a spacer in the construction of drug and other types of bioconjugates. 4-Maleimidobutyric acid is used with N-hydroxysuccinimide ester as a bifunctional cross-linking agent. Modification reagent for thiol gr |
4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29251900 |
4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid - Introduction
4-maleimidobutyric acid(4-maleimidobutyric acid) is an organic compound with the chemical formula C9H9NO4. It has the form of a white crystalline solid.
Nature:
4-maleimidobutyric acid is a highly reactive compound with strong nucleophilicity and acidity. It has low solubility in water and is stable at room temperature.
Use:
4-maleimidobutyric acid is an important organic synthesis intermediate, which is widely used in pharmaceutical research, biochemistry, preparation of functional materials and other fields. It is mainly used as a reagent for reacting with thiol groups, and is used for chemical modification reactions such as functionalization and cross-linking of modified proteins or biological macromolecules.
Preparation Method:
4-maleimidobutyric acid has many preparation methods, and the commonly used method is obtained by reacting 4-maleimido-1-carboxylic acid chloride with succinic acid. Specific preparation steps can refer to the relevant literature or professional manuals.
Safety Information:
4-maleimidobutyric acid is irritating and contact with skin and eyes may cause irritation or allergic reactions. Wear protective gloves and goggles during operation to prevent inhalation, ingestion or contact with skin. During storage and handling, avoid reaction with oxidants, acids, etc., and avoid fire sources and high temperatures. If you have any safety issues or discomfort, please seek professional medical help.
Nature:
4-maleimidobutyric acid is a highly reactive compound with strong nucleophilicity and acidity. It has low solubility in water and is stable at room temperature.
Use:
4-maleimidobutyric acid is an important organic synthesis intermediate, which is widely used in pharmaceutical research, biochemistry, preparation of functional materials and other fields. It is mainly used as a reagent for reacting with thiol groups, and is used for chemical modification reactions such as functionalization and cross-linking of modified proteins or biological macromolecules.
Preparation Method:
4-maleimidobutyric acid has many preparation methods, and the commonly used method is obtained by reacting 4-maleimido-1-carboxylic acid chloride with succinic acid. Specific preparation steps can refer to the relevant literature or professional manuals.
Safety Information:
4-maleimidobutyric acid is irritating and contact with skin and eyes may cause irritation or allergic reactions. Wear protective gloves and goggles during operation to prevent inhalation, ingestion or contact with skin. During storage and handling, avoid reaction with oxidants, acids, etc., and avoid fire sources and high temperatures. If you have any safety issues or discomfort, please seek professional medical help.
Last Update：2024-04-09 15:17:58
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Product Name: 4-Maleimidobutyric Acid Visit Supplier Webpage Request for quotation
CAS: 57078-98-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 57078-98-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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