4-(3-piridinyl)-2-pirimidine amine

4-(3-piridinyl)-2-pirimidine amine - Names and Identifiers

Name	4-(3-Pyridinyl)-2-aminopyrimidine
Synonyms	4-(3-Pyridyl)-2-pyrimidinamine 4-(3-Pyridyl)-2-pyrimidineamine 4-(3-PYRIDINYL)-2-PYRIMIDINAMINE 4-(3-Pyridinyl)-2-pyrimidinamine 4-(pyridin-3-yl)pyrimidin-2-amine 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE 4-(3-Pyridinyl)-2-aminopyrimidine 4-(3-Pyridinyl)-2-pyrimidine amine 4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE 4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE 4-(3-piridinyl)-2-pirimidine amine
CAS	66521-66-2
EINECS	1312995-182-4
InChI	InChI=1/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)

4-(3-piridinyl)-2-pirimidine amine - Physico-chemical Properties

Molecular Formula	C9H8N4
Molar Mass	172.19
Density	1.259±0.06 g/cm3(Predicted)
Melting Point	189-191 °C
Boling Point	439.9±37.0 °C(Predicted)
Flash Point	250°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	6.13E-08mmHg at 25°C
Appearance	Solid
Color	Off-White to Pale Yellow
pKa	2.76±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.641

4-(3-piridinyl)-2-pirimidine amine - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	R25 - Toxic if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves.
HS Code	29339900

4-(3-piridinyl)-2-pirimidine amine - Introduction

4-(3-Pyridinyl)-2-aminopyrimidine is an organic compound with the chemical formula C10H9N3. The following is a description of its nature, use, formulation and safety information:

Nature:
1. Appearance: 4-(3-Pyridinyl)-2-aminopyrimidine is a white crystalline solid.
2. solubility: it can be dissolved in water, can also be dissolved in organic solvents such as methanol and dichloromethane.
3. Melting point: Its melting point is 170-175°C.

Use:
1. Drug research: 4-(3-Pyridinyl)-2-aminopyrimidine is an organic synthetic intermediate widely used in drug research and can be used to synthesize a variety of biologically active compounds.
2. Anti-tumor drugs: Studies have shown that 4-(3-Pyridinyl)-2-aminopyrimidine has certain anti-tumor activity and can be used as follow-up research and development of anti-tumor drugs.

Preparation Method:
There are many preparation methods for 4-(3-Pyridinyl)-2-aminopyrimidine. The following is a typical preparation method:
3-pyridinecarboxaldehyde and 2-aminopyrimidine were reacted under alkaline conditions, and 4-(3-Pyridinyl)-2-aminopyrimidine was obtained by condensation reaction.

Safety Information:
1. 4-(3-Pyridinyl)-2-aminopyrimidine is not considered to have obvious toxicity under routine use conditions.
2. During operation, it is recommended to wear appropriate personal protective equipment, such as laboratory gloves and protective glasses.
3. avoid inhalation of its dust or solution, avoid contact with skin or eyes. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 15:18:00