4-(4-acetylphenyl)piperazin-1-ium

4-(4-acetylphenyl)piperazin-1-ium - Names and Identifiers

Name	4-Piperazinoacetophenone
Synonyms	NSC 109890 LABOTEST-BB LT00138218 4-Piperazinoacetophenone 4'-PIPERAZINOACETOPHENONE 4'-Piperazinoacetophenone 4'-poperazinoacetophenone piperazin-4-ylacetophenone N-(4-Acetylphenyl)piperazine 4'-(PIPERAZIN-4-YL)ACETOPHENONE 1-phenyl-2-piperazin-1-ylethanone 4-(4-acetylphenyl)piperazin-1-ium 1-[4-(piperazin-1-yl)phenyl]ethanone 1-(4-Acetylphenyl)piperazine, 1-[4-(Piperazin-1-yl)phenyl]ethan-1-one
CAS	51639-48-6
EINECS	257-332-6
InChI	InChI=1/C12H16N2O/c1-10(15)11-2-4-12(5-3-11)14-8-6-13-7-9-14/h2-5,13H,6-9H2,1H3/p+1

4-(4-acetylphenyl)piperazin-1-ium - Physico-chemical Properties

Molecular Formula

C12H16N2O

Molar Mass

204.27

Density

1.0565 (rough estimate)

Melting Point

107-110°C(lit.)

Boling Point

342.77°C (rough estimate)

Flash Point

185.1°C

Solubility

Benzene (Slightly, Heated), Chloroform (Slightly), DMSO (Slightly, Heated)

Vapor Presure

4.73E-06mmHg at 25°C

Appearance

Powder or Chunks

Color

Yellow

pKa

8.80±0.10(Predicted)

Storage Condition

2-8°C

Refractive Index

1.6000 (estimate)

MDL

MFCD00005962

Physical and Chemical Properties

mp (°C):

107

- 110

4-(4-acetylphenyl)piperazin-1-ium - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R21/22 - Harmful in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
UN IDs	3259
WGK Germany	3
HS Code	29335990
Hazard Note	Irritant
Hazard Class	8

4-(4-acetylphenyl)piperazin-1-ium - Introduction

4-Piperazinoacetophenone(4-Piperazinoacetophenone) is an organic compound with the chemical formula C12H16N2O. It had the appearance of a white crystalline powder.

Nature:
4-Piperazinoacetophenone is a solid substance with a strong odor. It has moderate solubility and is soluble in most organic solvents such as ethanol, ethers and chlorinated hydrocarbons. It is stable at room temperature, but it is easy to burn under the action of high temperature, open flame and strong oxidant. In addition, it is irritating to the eyes and skin.

Use:
4-Piperazinoacetophenone is useful as a pharmaceutical intermediate. It is often used in the pharmaceutical industry to synthesize various drugs, especially antipsychotic drugs such as chlorpromazine. In addition, it can also be used in organic synthesis reactions, such as Bodroux-Chichibabin reactions.

Preparation Method:
The synthesis of 4-Piperazinoacetophenone can be achieved by the reaction of piperazine and phenylacetic acid. First, piperazine is reacted with a basic alcohol or alcohol-water mixture under acidic conditions to produce N-piperazinylacetic acid. Then, N-piperazinylacetic acid and acetophenone were subjected to oxidative condensation reaction to give 4-Piperazino acetophenone.

Safety Information:
When handling and storing 4-Piperazinoacetophenone, take care to avoid inhalation, swallowing, and contact with skin. In case of skin contact, rinse immediately with plenty of water and seek medical help. Keep away from open flames and high temperature sources and store in a dry, well-ventilated place. In addition, the use and handling of the compound must strictly follow the relevant safety procedures.

Last Update：2024-04-09 21:01:54