4-(4-chlorobenzyl)phthalazin-1(2H)-one

4-(4-chlorobenzyl)phthalazin-1(2H)-one - Names and Identifiers

Name	4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one
Synonyms	Azelastine Impurity D(USP) Azelastine Related CoMpound D Phthalazinone Azelastine Analog 4-(4-chlorobenzyl)phthalazin-1(2H)-one 4-(4-Chlorobenzyl)-1(2H)-phthalazinone 4-(4-Chloro-benzyl)-2H-phthalazin-1-one 4-(4-chloro-benzyl)-2h-phthalazin-1-one 4-((4-Chlorophenyl)methyl)phthalazin-1(2H)-one 4-[(4-Chlorophenyl)methyl]-1(2H)-phthalazinone 4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one 4-[(4-chlorophenyl)methyl]phthalazin-1(2h)-one 4-(4-Chlorobenzyl)-1,2-dihydrophthalazine-1-one
CAS	53242-88-9
EINECS	258-445-3
InChI	InChI=1/C15H11ClN2O/c16-11-7-5-10(6-8-11)9-14-12-3-1-2-4-13(12)15(19)18-17-14/h1-8H,9H2,(H,18,19)

4-(4-chlorobenzyl)phthalazin-1(2H)-one - Physico-chemical Properties

Molecular Formula	C15H11ClN2O
Molar Mass	270.71
Density	1.32±0.1 g/cm3(Predicted)
Melting Point	206-207 °C(Solv: ethanol (64-17-5))
Boling Point	522.3°C at 760 mmHg
Flash Point	269.7°C
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure	1.57E-11mmHg at 25°C
Appearance	neat
Color	White to Off-White
pKa	12.08±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.66

4-(4-chlorobenzyl)phthalazin-1(2H)-one - Risk and Safety

HS Code

2933998350

4-(4-chlorobenzyl)phthalazin-1(2H)-one - Introduction

4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one is an organic compound with the chemical formula C17H12ClNO and a molecular weight of 295.73g/mol. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystal or crystalline powder
-Melting point: 116-118°C
-Solubility: Insoluble in water, slightly soluble in ethanol, acetone and dichloromethane
-Chemical properties: 4-[(4-chlorophyll) methyl]phthalazin-1(2H)-one is an organic ketone compound with moderate chemical stability.

Use:
-Drug research: 4-[(4-chlorophyll) methyl]phthalazin-1(2H)-one is an important drug intermediate, which is widely used in the synthesis of various biologically active organic compounds.
-Antibacterial agent: The compound has certain antibacterial activity and can be used in drug research and development or pesticide manufacturing.

Preparation Method:
4-[(4-chlorophyll) methyl]phthalazin-1(2H)-one has various synthesis methods, and common preparation methods include:
-Ketonation reaction: 4-Chlorobenzyl-phthalazinone is reacted with a ketonizing agent under alkaline conditions to give 4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one.
-Reduction reaction: 4-chlorobenzyl -1-(2H)-phthalazinone is reacted with a reducing agent, and then separated and purified to obtain the target product.

Safety Information:
When used and handled correctly, 4-[(4-chlorophyll) methyl]phthalazin-1(2H)-one is generally less toxic. However, it can be irritating to the eyes and skin and direct contact should be avoided. Wear protective gloves, goggles, and protective clothing when you use or handle the compound. At the same time, the compound should also be stored in a dry, well-ventilated place, avoid contact with oxidants. In case of accidental ingestion or inadvertent contact, seek medical attention immediately.

Last Update：2024-04-09 21:11:58