4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole

4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole - Names and Identifiers

Name	5-phenyl-1,3-oxazole-4-carbonyl chloride
Synonyms	5-Phenyloxazole-4-carbonyl chloride 5-phenyloxazole-4-carbonyl chloride 4-Oxazolecarbonyl chloride, 5-phenyl- 4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole 5-PHENYL-1,3-OXAZOLE-4-CARBONYL CHLORIDE 5-phenyl-1,3-oxazole-4-carbonyl chloride 4-Oxazolecarbonyl chloride, 5-phenyl- (9CI)
CAS	337508-64-2
InChI	InChI=1/C10H6ClNO2/c11-10(13)8-9(14-6-12-8)7-4-2-1-3-5-7/h1-6H

4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole - Physico-chemical Properties

Molecular Formula	C10H6ClNO2
Molar Mass	207.61
Density	1.321g/cm³
Melting Point	74 °C
Boling Point	357.187°C at 760 mmHg
Flash Point	169.821°C
Vapor Presure	0mmHg at 25°C
Storage Condition	Room Temprature
Refractive Index	1.569

4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Hazard Note	Corrosive

4-(Chlorocarbonyl)-5-phenyl-1,3-oxazole - Introduction

5-phenyl-1,3-oxazole-4-carbonyl chloride is an organic compound with the chemical formula C10H6ClNO2. It is colorless to yellowish crystals with a strong pungent odor. The compound has a relatively high melting point and boiling point, is insoluble in water, but is soluble in organic solvents such as ethanol and methylene chloride.

5-phenyl-1,3-oxazole-4-carbonyl chloride is mainly used as a reagent in organic synthesis. It can be used in the synthesis of derivatives of phenyl ketones and phenyl acids, as well as in the synthesis of biologically active compounds. It has a wide range of applications in the field of medicine and pesticides.

The method for preparing 5-phenyl-1,3-oxazole-4-carbonyl chloride is generally by adding thionyl chloride to acetic acid, and then adding thionyl chloride and reacting with acetophenone to produce the corresponding aldehyde. Next, the aldehyde and isocyanate chloride are condensed to form the corresponding 2-amino -5-phenyl -1, 3-oxazole, and finally chlorinated to obtain the target product.

Regarding safety information, 5-phenyl-1,3-oxazole-4-carbonyl chloride is an irritant compound. Care should be taken to avoid skin contact and inhalation during operation. Should be operated in a well-ventilated place, wear protective gloves, protective glasses and masks. In case of contact with skin, rinse immediately with plenty of water and seek medical help. If inhaled or ingested, seek medical help immediately.

Last Update：2024-04-09 20:02:46