4-Benzyloxy-piperidine Hydrochloride

4-Benzyloxy-piperidine Hydrochloride - Names and Identifiers

Name	4-Benzyloxy-piperidine Hydrochloride
Synonyms	4-Benzyloxy-piperidine HCl 4-BENZYLOXY-PIPERIDINE HCL 4-Benzyloxy-piperidine Hydrochloride 4-BENZYLOXY-PIPERIDINE HYDROCHLORIDE
CAS	81151-68-0

4-Benzyloxy-piperidine Hydrochloride - Physico-chemical Properties

Molecular Formula	C12H18ClNO
Molar Mass	227.73

4-Benzyloxy-piperidine Hydrochloride - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

4-Benzyloxy-piperidine Hydrochloride - Introduction

4-Benzyloxy-piperidine Hydrochloride is an organic compound with the chemical formula C12H17NO · HCl. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White to light yellow solid
-Melting point: 141-144°C
-Molecular weight: 227.74g/mol
-Solubility: Soluble in water and some organic solvents, such as alcohols, ethers and chloroform

Use:
4-benzyloxy-piperidine Hydrochloride has important applications in the pharmaceutical field. It is often used as an intermediate in organic synthesis for the preparation of other compounds. It is also used in the synthesis of some drugs, such as the antipsychotic drug chlorpromazine (Chlorpromazine) and the antihypertensive drug piperidine (Pindolol).

Preparation Method:
4-Benzyloxy-piperidine Hydrochloride is mainly prepared by reacting piperidine with benzyl alcohol to generate benzyloxy piperidine, and then reacting with hydrochloric acid to obtain hydrochloride. The specific preparation method can be:
1. Piperidine was dissolved in anhydrous xylene under an inert atmosphere.
2. Add benzyl alcohol and catalyst and heat the reaction mixture.
3. After completion of the reaction, the reaction mixture was cooled and acidified with hydrochloric acid.
4. The solid was filtered, washed and dried to give 4-benzyloxy-piperidine Hydrochloride.

Safety Information:
-4-benzyloxy-piperidine Hydrochloride dust and solution may be irritating to the eyes, skin and respiratory tract, should be careful to avoid contact.
-During operation, use appropriate personal protective equipment, such as chemical protective glasses, gloves and protective masks.
-The compound should be stored in a dry, well-ventilated place, away from high temperatures and sources of fire.
-When handling or disposing of waste, observe local safe practices and environmental regulations.

Last Update：2024-04-09 02:00:48