4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE - Names and Identifiers
4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE - Physico-chemical Properties
| Molecular Formula | C6HClF3N3
|
| Molar Mass | 207.5404496 |
4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE - Introduction
4-choro-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE is an organic compound with the chemical formula C6H2ClF3N2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless crystal
-Melting point: 122-123 ° C
-Boiling point: 221 ° C
-Density: 1.63g/cm³
Use:
- 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE is an important intermediate commonly used in organic synthesis reactions.
-It can be used in the synthesis of pesticides, pharmaceuticals and other organic compounds.
Method:
4-choro-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE has many preparation methods, and a common method is as follows:
1.2-(trifluoromethyl) pyridine and carbon tetrachloride are reacted in the presence of dimethyl sulfoxide to generate 2-(trifluoromethyl) pyridine-4-carboxylate.
2. Reaction of 2-(trifluoromethyl) pyridine-4-carboxylate with Carbon dichloride in a solvent of dichloroacetonitrile and methanol yields 4-chloro-2-(trifluoromethyl) pyridine.
3. Finally, 4-CHLORO-2-(TRIFLUOROMETHYL) pyridine is reacted with sodium cyanide to generate 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE.
Safety Information:
- 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONITRILE is irritating and may cause irritation to the eyes, skin and respiratory system.
-Wear appropriate personal protective equipment such as safety glasses, protective gloves and protective masks during use and handling.
-Avoid contact with skin, eyes and clothing. Do not breathe its vapor or dust.
-Keep away from fire and oxidant when stored, keep sealed, and store in a well-ventilated place.
Last Update：2024-04-09 21:00:56